LOYOLA
Research

Oferta científica
y grupos de investigación


VALERIA PINGITORE

VALERIA PINGITORE

Categoría: Profesor/a Ayudante Doctor/a
Área de conocimiento:
ORCID iD: 0009-0001-0997-9628
Grupo de Investigación: Loyola Biomedical Research
Departamento de Salud

Publicaciones

I am a Lecturer in Organic and Pharmaceutical Chemistry at the Universidad Loyola Andalucia. I taught Organic Chemistry I and II for 4 years at the International University Centre of the Pablo de Olavide University (UPO, Seville) in collaboration with the University of New England (UNE, Maine, United States) at a course directed to US students. I have been part of the teaching staff of the Master of Drug Design of the University College London (UCL). My research focuses on Molecular Modelling Design, Organic Synthesis and Biological assays of next generation drugs and molecular probes. My main research fields are Targeted Protein Degradation (TPD, PROTACs) and Chemical Proteomics (Photo-affinity labeling - PAL). I did my Postdoc in Medicinal Chemistry and Chemical Biology in the Drug Discovery group of the Wolfson Institute for Biomedical Research, within the Faculty of Medical Sciences of the University College London - UCL. My research was financed by the prestigious Wellcome Trust foundation and focused on the development of new Cyclosporine based molecules as next generation Antiviral drugs (anti-HIV) and new Gene Therapy treatments. The results of this research have been patented and presented at some of the best scientific conferences in the UK (London, Oxford, etc). I worked as a Senior Synthetic Chemist in the R&D department of the  Oxfordshire-based company Biosynth, where I specialized in the multistep synthesis of oligosaccharides, oligonucleotides and oligopeptide derivatives for the biotechnology, pharmaceutical and academic sectors. I obtained my PhD in Organic Chemistry at the University of Seville presenting a thesis on the parallel synthesis of new enzyme inhibitors via click chemistry (CuAAC) for the treatment of Lysosomal Storage Diseases (LSDs). My passion for science and the awareness that studying abroad is profoundly important for achieving new scientific and professional goals, has pushed me to complete an additional Master\'s degree in Advanced Studies in Chemistry at the faculty of Chemistry of the University of Seville presenting a Master\'s thesis on the synthesis of new multivalent glycosidase inhibitors based on an iminosugar structure. I obtained my "Laurea Magistrale" (Single cycle degree/Combined Bachelor and Master- 5 years course; Esp. Licenciatura: Grado + Máster) in Chemistry and Pharmaceutical Technologies at the University of Calabria (Italy) presenting a Master\'s thesis in Organic Chemistry on the recyclable synthesis of iodothiophenes by iodocyclization in ionic liquids (Green Chemistry).

Artículos o Reviews

Publicación
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
PINGITORE, VALERIA, Martinez-Bailen, Macarena , Carmona, Ana T. , Meszaros, Zuzana , Kulik, Natalia , Slamova, Kristyna , Kren, Vladimir , Bojarova, Pavla , Robina, Inmaculada , Moreno-Vargas, Antonio J.
01/03/2022
Article
Discovery of a Potent a-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry
Elias-Rodriguez, Pilar , PINGITORE, VALERIA, Carmona, Ana T. , Moreno-Vargas, Antonio J. , Ide, Daisuke , Miyawaki, Shota , Kato, Atsushi , Alvarez, Eleuterio , Robina, Inmaculada
17/08/2018
Article
Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors
Carmona, Ana T. , Carrion-Jimenez, Sebastian , PINGITORE, VALERIA, Moreno-Clavijo, Elena , Robina, Inmaculada , Moreno-Vargas, Antonio J.
10/05/2018
Article

Conference Paper o Proceedings Paper o Ponencia del congreso o Abstract de un congreso

Publicación
Novel Cyclosporin-like molecules inhibit the antiviral restriction factor IFITM3 to enhance stem cell Gene Therapy
PINGITORE, VALERIA, Selwood, David
09/12/2022
Ponencia del Congreso
Discovery of human hexosaminidase inhibitors by in situ screening of a\r\nlibrary of mono- and divalent pyrrolidine iminosugars
PINGITORE, VALERIA
16/10/2019
Ponencia del Congreso
Síntesis y evaluación biológica in situ de potentes inhibidores de glicosidasas con estructura de pirrolidin/indolizidin-(tio)urea
PINGITORE, VALERIA, Elías Rodríguez, Maria del Pilar , CARMONA ASENJO, ANA TERESA , Ide, Daisuke , Kato, Atsushi , MORENO VARGAS, ANTONIO JOSÉ , ROBINA RAMÍREZ, INMACULADA
17/10/2018
Ponencia del Congreso
CuAAC and in situ screening for the rapid discovery of divalent glycosidase inhibitors
MORENO VARGAS, ANTONIO JOSÉ , CARMONA ASENJO, ANA TERESA , Carrión Jiménez, Sebastián , PINGITORE, VALERIA, MORENO CLAVIJO, ELENA , ROBINA RAMÍREZ, INMACULADA
14/07/2018
Ponencia del Congreso
Click chemistry and in situ biological screening in the discovery of glycosidase inhibitors
Martínez Bailén, Macarena , Elías Rodríguez, Maria del Pilar , PINGITORE, VALERIA, MORENO VARGAS, ANTONIO JOSÉ , CARMONA ASENJO, ANA TERESA , ROBINA RAMÍREZ, INMACULADA , MORENO CLAVIJO, ELENA
03/09/2017
Ponencia del Congreso

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