I am a Lecturer in Organic and Medicinal Chemistry at Loyola University in Seville. I completed my PhD in Organic Chemistry at the University of Seville, focusing on the synthesis of new glycosidase inhibitors using click chemistry. Afterward, I worked as a Senior Scientist at the Oxfordshire-based company Biosynth, specializing in the synthesis of complex natural products and small molecules. I also held a postdoctoral position in Medicinal Chemistry and Chemical Biology in the Drug Discovery group, led by Professor David Selwood, at the Wolfson Institute for Biomedical Research, within the Faculty of Medical Sciences at University College London (UCL). My research interests include peptide-based drug discovery, Targeted Protein Degradation (TPD), and chemical proteomics. Outside of work, I enjoy fencing, traveling, and cooking.
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Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration PINGITORE, VALERIA, Pancholi, Jessica , Hornsby, Thomas W. , Warne, Justin , Pryce, Gareth , Mccormick, Laura J. , Hill, Julia , Bhosale, Gauri , Peng, Jing , Newton, Lydia S. , Towers, Greg J. , Coles, Simon J. , Chan, Ah Wing Edith , Duchen, Michael R. , Szabadkai, Gyorgy , Baker, David , Selwood, David L. 10/07/2024 Article |
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars PINGITORE, VALERIA, Martinez-Bailen, Macarena , Carmona, Ana T. , Meszaros, Zuzana , Kulik, Natalia , Slamova, Kristyna , Kren, Vladimir , Bojarova, Pavla , Robina, Inmaculada , Moreno-Vargas, Antonio J. 01/03/2022 Article |
Discovery of a Potent a-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry Elias-Rodriguez, Pilar , PINGITORE, VALERIA, Carmona, Ana T. , Moreno-Vargas, Antonio J. , Ide, Daisuke , Miyawaki, Shota , Kato, Atsushi , Alvarez, Eleuterio , Robina, Inmaculada 17/08/2018 Article |
Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors Carmona, Ana T. , Carrion-Jimenez, Sebastian , PINGITORE, VALERIA, Moreno-Clavijo, Elena , Robina, Inmaculada , Moreno-Vargas, Antonio J. 10/05/2018 Article |
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NEW FRONTIERS IN CNS PENETRATION: DELOCALIZED QUINOLINIUM-MACROCYCLIC PEPTIDES AS GAME-CHANGING CHEMOTYPES PINGITORE, VALERIA 29/01/2025 - 31/01/2025 Ponencia del Congreso |
Novel Cyclosporin-like molecules inhibit the antiviral restriction factor IFITM3 to enhance stem cell Gene Therapy PINGITORE, VALERIA, Selwood, David 09/12/2022 Ponencia del Congreso |
Discovery of human hexosaminidase inhibitors by in situ screening of a\r\nlibrary of mono- and divalent pyrrolidine iminosugars PINGITORE, VALERIA 16/10/2019 Ponencia del Congreso |
Síntesis y evaluación biológica in situ de potentes inhibidores de glicosidasas con estructura de pirrolidin/indolizidin-(tio)urea PINGITORE, VALERIA, Elías Rodríguez, Maria del Pilar , CARMONA ASENJO, ANA TERESA , Ide, Daisuke , Kato, Atsushi , MORENO VARGAS, ANTONIO JOSÉ , ROBINA RAMÍREZ, INMACULADA 17/10/2018 Ponencia del Congreso |
CuAAC and in situ screening for the rapid discovery of divalent glycosidase inhibitors MORENO VARGAS, ANTONIO JOSÉ , CARMONA ASENJO, ANA TERESA , Carrión Jiménez, Sebastián , PINGITORE, VALERIA, MORENO CLAVIJO, ELENA , ROBINA RAMÍREZ, INMACULADA 14/07/2018 Ponencia del Congreso |
Click chemistry and in situ biological screening in the discovery of glycosidase inhibitors Martínez Bailén, Macarena , Elías Rodríguez, Maria del Pilar , PINGITORE, VALERIA, MORENO VARGAS, ANTONIO JOSÉ , CARMONA ASENJO, ANA TERESA , ROBINA RAMÍREZ, INMACULADA , MORENO CLAVIJO, ELENA 03/09/2017 Ponencia del Congreso |
Proyecto |
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Explorando los mecanismos moleculares del endotelio en la calcificación de la válvula aórtica: desarrollo de nuevas estrategias
farmacológicas a través de la modulacióndeNotch Project 01/09/2024 Amount: 125000 € Principal Investigator: MACARENA FERNÁNDEZ CHACÓN CO IP: JOSÉ ANTONIO ORDÓÑEZ FERNÁNDEZ |
Proyecto externo |
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Chemical approaches to target cancer: new cytotoxic compounds and delivery system strategies Fecha de inicio del proyecto: 01/08/2024 |
New scaffolds for edelfosine analogs and simpler analogues of FK866 Fecha de inicio del proyecto: 01/10/2017 |
Integrating Chemical Approaches to treat Pancreatic Cancer: making new leads for a cure (PANACREAS) Fecha de inicio del proyecto: 01/10/2016 |