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Research

Scientific offer
and research groups


VALERIA PINGITORE

VALERIA PINGITORE

Category: Assistant Professor/Tenure Track
Area of knowledge:
ORCID iD: 0009-0001-0997-9628
Research Unit: Loyola Biomedical Research
Departamento de Salud

Publications

I am a Lecturer in Organic and Medicinal Chemistry at Loyola University in Seville. I completed my PhD in Organic Chemistry at the University of Seville, focusing on the synthesis of new glycosidase inhibitors using click chemistry. Afterward, I worked as a Senior Scientist at the Oxfordshire-based company Biosynth, specializing in the synthesis of complex natural products and small molecules. I also held a postdoctoral position in Medicinal Chemistry and Chemical Biology in the Drug Discovery group, led by Professor David Selwood, at the Wolfson Institute for Biomedical Research, within the Faculty of Medical Sciences at University College London (UCL). My research interests include peptide-based drug discovery, Targeted Protein Degradation (TPD), and chemical proteomics. Outside of work, I enjoy fencing, traveling, and cooking.

Artículos o Reviews

Publicación
Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration
PINGITORE, VALERIA, Pancholi, Jessica , Hornsby, Thomas W. , Warne, Justin , Pryce, Gareth , Mccormick, Laura J. , Hill, Julia , Bhosale, Gauri , Peng, Jing , Newton, Lydia S. , Towers, Greg J. , Coles, Simon J. , Chan, Ah Wing Edith , Duchen, Michael R. , Szabadkai, Gyorgy , Baker, David , Selwood, David L.
10/07/2024
Article
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
PINGITORE, VALERIA, Martinez-Bailen, Macarena , Carmona, Ana T. , Meszaros, Zuzana , Kulik, Natalia , Slamova, Kristyna , Kren, Vladimir , Bojarova, Pavla , Robina, Inmaculada , Moreno-Vargas, Antonio J.
01/03/2022
Article
Discovery of a Potent a-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry
Elias-Rodriguez, Pilar , PINGITORE, VALERIA, Carmona, Ana T. , Moreno-Vargas, Antonio J. , Ide, Daisuke , Miyawaki, Shota , Kato, Atsushi , Alvarez, Eleuterio , Robina, Inmaculada
17/08/2018
Article
Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors
Carmona, Ana T. , Carrion-Jimenez, Sebastian , PINGITORE, VALERIA, Moreno-Clavijo, Elena , Robina, Inmaculada , Moreno-Vargas, Antonio J.
10/05/2018
Article

Conference Paper o Proceedings Paper o Ponencia del congreso o Abstract de un congreso

Publicación
NEW FRONTIERS IN CNS PENETRATION: DELOCALIZED QUINOLINIUM-MACROCYCLIC PEPTIDES AS GAME-CHANGING CHEMOTYPES
PINGITORE, VALERIA
29/01/2025 - 31/01/2025
Ponencia del Congreso
Novel Cyclosporin-like molecules inhibit the antiviral restriction factor IFITM3 to enhance stem cell Gene Therapy
PINGITORE, VALERIA, Selwood, David
09/12/2022
Ponencia del Congreso
Discovery of human hexosaminidase inhibitors by in situ screening of a\r\nlibrary of mono- and divalent pyrrolidine iminosugars
PINGITORE, VALERIA
16/10/2019
Ponencia del Congreso
Síntesis y evaluación biológica in situ de potentes inhibidores de glicosidasas con estructura de pirrolidin/indolizidin-(tio)urea
PINGITORE, VALERIA, Elías Rodríguez, Maria del Pilar , CARMONA ASENJO, ANA TERESA , Ide, Daisuke , Kato, Atsushi , MORENO VARGAS, ANTONIO JOSÉ , ROBINA RAMÍREZ, INMACULADA
17/10/2018
Ponencia del Congreso
CuAAC and in situ screening for the rapid discovery of divalent glycosidase inhibitors
MORENO VARGAS, ANTONIO JOSÉ , CARMONA ASENJO, ANA TERESA , Carrión Jiménez, Sebastián , PINGITORE, VALERIA, MORENO CLAVIJO, ELENA , ROBINA RAMÍREZ, INMACULADA
14/07/2018
Ponencia del Congreso
Click chemistry and in situ biological screening in the discovery of glycosidase inhibitors
Martínez Bailén, Macarena , Elías Rodríguez, Maria del Pilar , PINGITORE, VALERIA, MORENO VARGAS, ANTONIO JOSÉ , CARMONA ASENJO, ANA TERESA , ROBINA RAMÍREZ, INMACULADA , MORENO CLAVIJO, ELENA
03/09/2017
Ponencia del Congreso

Proyectos de investigación

Proyecto
Explorando los mecanismos moleculares del endotelio en la calcificación de la válvula aórtica: desarrollo de nuevas estrategias farmacológicas a través de la modulacióndeNotch
Project
01/09/2024
Amount: 125000 €
Principal Investigator: MACARENA FERNÁNDEZ CHACÓN
CO IP: JOSÉ ANTONIO ORDÓÑEZ FERNÁNDEZ

Proyectos externos de investigación

Proyecto externo
Chemical approaches to target cancer: new cytotoxic compounds and delivery system strategies
Fecha de inicio del proyecto: 01/08/2024
New scaffolds for edelfosine analogs and simpler analogues of FK866
Fecha de inicio del proyecto: 01/10/2017
Integrating Chemical Approaches to treat Pancreatic Cancer: making new leads for a cure (PANACREAS)
Fecha de inicio del proyecto: 01/10/2016