| Título | Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial |
|---|---|
| Autores | Vazquez-Lorente, Hector , Herrera-Quintana, Lourdes , Ruiz, Jonatan R. , Amaro-Gahete, Francisco J. , CARNEIRO BARRERA, ALMUDENA |
| Publicación externa | No |
| Medio | Sleep Med |
| Alcance | Article |
| Naturaleza | Científica |
| Cuartil JCR | 1 |
| Cuartil SJR | 1 |
| Fecha de publicacion | 01/04/2025 |
| ISI | 001414519200001 |
| DOI | 10.1016/j.sleep.2025.01.011 |
| Abstract | Introduction: Vitamin D deficiency is commonly found among patients with obstructive sleep apnea (OSA). We aimed to determine the effect of an eight-week interdisciplinary weight loss and lifestyle intervention on circulating vitamin D levels in patients with moderate-to-severe OSA. Methods: 89 men were assigned to a usual-care group (n = 49) or an 8-week interdisciplinary weight loss and lifestyle intervention combined with usual-care (n = 40). Evaluations were conducted at baseline, intervention endpoint (i.e., 8 weeks), and 6 months post-intervention. Serum 25-hydroxyvitamin D (25(OH)D) was determined using a chemiluminescence immunoassay. Sleep (i.e., sleep efficiency, apnea-hypopnea index [AHI], and oxygen desaturation index) and body weight and composition (i.e., fat mass, and visceral adipose tissue) variables were also determined. Results: Serum 25(OH)D concentrations showed an insufficient vitamin D status at baseline, which significantly increased (all p < 0.034) at intervention endpoint (19 %) and at 6 months after intervention (45 %) in the intervention group to the point of potentially resolving vitamin D deficiency. Higher serum 25(OH)D concentrations were related to increased sleep efficiency and reduced AHI, oxygen desaturation index, and body weight and composition variables (all p < 0.001) from baseline to 6 months and from 8 weeks to 6 months after intervention. These results were also noted from baseline to 8 weeks, except for body composition (all p < 0.007). Conclusion: The intervention improved and potentially resolved vitamin D deficiency. Together with the improvement of adverse sleep patterns and body composition parameters, it may be considered as a promising approach in the treatment of OSA. |
| Palabras clave | Obstructive sleep apnea; Obesity; Weight loss; Lifestyle intervention; Vitamin D; Sleep |
| Miembros de la Universidad Loyola |