| Título | Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats |
|---|---|
| Autores | CASUSO PÉREZ, RAFAEL, Al Fazazi, Saad , Ruiz-Ojeda, Francisco J. , Plaza-Diaz, Julio , Rueda-Robles, Ascension , Aragon-Vela, Jeronimo , Huertas, Jesus R. |
| Publicación externa | Si |
| Medio | J. Cell. Physiol. |
| Alcance | Article |
| Naturaleza | Científica |
| Cuartil JCR | 1 |
| Cuartil SJR | 1 |
| Impacto JCR | 6.513 |
| Impacto SJR | 1.308 |
| Fecha de publicacion | 01/01/2021 |
| ISI | 000540196300001 |
| DOI | 10.1002/jcp.29876 |
| Abstract | Training induces a number of healthy effects including a rise in skeletal muscle (SKM) glucose uptake. These adaptations are at least in part due to the reactive oxygen species produced within SKM, which is in agreement with the notion that antioxidant supplementation blunts some training-induced adaptations. Here, we tested whether hydroxytyrosol (HT), the main polyphenol of olive oil, would modify the molecular regulators of glucose uptake when HT is supplemented during exercise. Rats were included into sedentary and exercised (EXE) groups. EXE group was further divided into a group consuming a low HT dose (0.31 mg center dot kg center dot d; EXElow), a moderate HT dose (4.61 mg center dot kg center dot d; EXEmid), and a control group (EXE). EXE raised glucose transporter type 4 (GLUT4) protein content, Ras-related C3 botulinum toxin substrate 1 (Rac1) activity, and protein kinase b (AKT) phosphorylation in SKM. Furthermore, EXElow blunted GLUT4 protein content and AKT phosphorylation while EXEmid showed a downregulation of the GLUT4/AKT/Rac1 axis. Hence, a low-to-moderate dose of HT, when it is supplemented as an isolated compound, might alter the beneficial effect of training on basal AKT phosphorylation and Rac1 activity in rats. |
| Palabras clave | antioxidants; exercise; glucose; polyphenols; skeletal muscle |
| Miembros de la Universidad Loyola |