| Título |
Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment |
| Autores |
Aragon-Vela, Jeronimo , CASUSO PÉREZ, RAFAEL, Aparisi, Ana Sagrera , Plaza-Diaz, Julio , Rueda-Robles, Ascension , Hidalgo-Gutierrez, Agustin , Lopez, Luis Carlos , Rodriguez-Carrillo, Andrea , Enriquez, Jose Antonio , Cogliati, Sara , Huertas, Jesus R. |
| Publicación externa |
No |
| Medio |
JOURNAL OF PHYSIOLOGY-LONDON |
| Alcance |
Article |
| Naturaleza |
Científica |
| Cuartil JCR |
1 |
| Cuartil SJR |
1 |
| Web |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191022273&doi=10.1113%2fJP285516&partnerID=40&md5=18484178fcf1dffcf9a3b7119b13d245 |
| Fecha de publicacion |
17/04/2024 |
| ISI |
001204087400001 |
| Scopus Id |
2-s2.0-85191022273 |
| DOI |
10.1113/JP285516 |
| Abstract |
In eukaryotic cells, aerobic energy is produced by mitochondria through oxygen uptake. However, little is known about the early mitochondrial responses to moderate hypobaric hypoxia (MHH) in highly metabolic active tissues. Here, we describe the mitochondrial responses to acute MHH in the heart and skeletal muscle. Rats were randomly allocated into a normoxia control group (n = 10) and a hypoxia group (n = 30), divided into three groups (0, 6, and 24 h post-MHH). The normoxia situation was recapitulated at the University of Granada, at 662 m above sea level. The MHH situation was performed at the High-Performance Altitude Training Centre of Sierra Nevada located in Granada at 2320 m above sea level. We found a significant increase in mitochondrial supercomplex assembly in the heart as soon as the animals reached 2320 m above sea level and their levels are maintained 24 h post-exposure, but not in skeletal muscle. Furthermore, in skeletal muscle, at 0 and 6 h, there was increased dynamin-related protein 1 (Drp1) expression and a significant reduction in Mitofusin 2. In conclusion, mitochondria from the muscle and heart respond differently to MHH: mitochondrial supercomplexes increase in the heart, whereas, in skeletal muscle, the mitochondrial pro-fission response is trigged. Considering that skeletal muscle was not actively involved in the ascent when the heart was beating faster to compensate for the hypobaric, hypoxic conditions, we speculate that the different responses to MHH are a result of the different energetic requirements of the tissues upon MHH. |
| Palabras clave |
heart; mitochondria; moderate hypobaric hypoxia; skeletal muscle; supercomplexes |
| Miembros de la Universidad Loyola |
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