| Title | Tramadol effects on physical performance and sustained attention during a 20-min indoor cycling time-trial: A randomised controlled trial |
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| Authors | Holgado, Darias , Zandonai, Thomas , Zabala, Mikel , Hopker, James , PERAKAKIS, PANTELIS, Luque-Casado, Antonio , Ciria, Luis , Guerra-Hernandez, Eduardo , Sanabria, Daniel |
| External publication | No |
| Means | J. Sci. Med. Sport |
| Scope | Article |
| Nature | Científica |
| JCR Quartile | 1 |
| SJR Quartile | 1 |
| JCR Impact | 3.623 |
| Web | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034434710&doi=10.1016%2fj.jsams.2017.10.032&partnerID=40&md5=bbdb6fb580cd3a93a16e551041f37119 |
| Publication date | 01/07/2018 |
| ISI | 000436384000003 |
| Scopus Id | 2-s2.0-85034434710 |
| DOI | 10.1016/j.jsams.2017.10.032 |
| Abstract | Objectives: To investigate the effect of tramadol on performance during a 20-min cycling time-trial (Experiment 1), and to test whether sustained attention would be impaired during cycling after tramadol intake (Experiment 2).\n Design: Randomized, double-blind, placebo controlled trial.\n Methods: In Experiment 1, participants completed a cycling time-trial, 120-min after they ingested either tramadol or placebo. In Experiment 2, participants performed a visual oddball task during the time-trial. Electroencephalography measures (EEG) were recorded throughout the session.\n Results: In Experiment 1, average time-trial power output was higher in the tramadol vs. placebo condition (tramadol: 220W vs. placebo: 209W; p<0.01). In Experiment 2, no differences between conditions were observed in the average power output (tramadol: 234W vs. placebo: 230W; p>0.05). No behavioural differences were found between conditions in the oddball task. Crucially, the time frequency analysis in Experiment 2 revealed an overall lower target-locked power in the beta-band (p<0.01), and higher alpha suppression (p<0.01) in the tramadol vs. placebo condition. At baseline, EEG power spectrum was higher under tramadol than under placebo in Experiment 1 while the reverse was true for Experiment 2.\n Conclusions: Tramadol improved cycling power output in Experiment 1, but not in Experiment 2, which may be due to the simultaneous performance of a cognitive task. Interestingly enough, the EEG data in Experiment 2 pointed to an impact of tramadol on stimulus processing related to sustained attention. Trial registration: EudraCT number: 2015-005056-96. Crown Copyright (C) 2017 Published by Elsevier Ltd on behalf of Sports Medicine Australia. All rights reserved. |
| Keywords | Doping in sport; Opioid analgesic; Athletes; EEG; Exercise; Brain |
| Universidad Loyola members |
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