| Authors |
GIL COSANO, JOSÉ JUAN, Gracia-Marco, Luis , Ubago-Guisado, Esther , Labayen, Idoia , Adelantado-Renau, Mireia , Cadenas-Sanchez, Cristina , Mora-Gonzalez, Jose , Plaza-Florido, Abel , Aguilera, Concepcion M. , Gomez-Vida, Jose , Maldonado, Jose , Jurimae, Jaak , Ortega, Francisco B. |
| Abstract |
OBJECTIVES: To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.\n METHODS: Plasma interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry.\n RESULTS: IL-6 (beta=-0.136) and VEGF (beta=-0.099) were associated with TBLH BMC, while TNF-alpha (beta=-0.345) and IL-1 beta (beta = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P= 0.122) and TNF-alpha with LS BMC (P=0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (beta=-0.152) and TNF-alpha with LS BMC (beta=-0.491) in the low-fitness group, while no association was found in the highfitness group.\n CONCLUSION: IL-6, VEGF, TNF-alpha, and IL-1 beta are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-alpha on bone mass. |
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