| Title |
Pneumocystis jirovecii infection in patients with acute interstitial pneumonia |
| Authors |
Martinez-Risquez, M. T. , Friaza, V , DE LA HORRA PADILLA, CARMEN, Martin-Juan, J. , Calderon, E. J. , Medrano, F. J. |
| External publication |
Si |
| Means |
REVISTA CLINICA ESPANOLA |
| Scope |
Article |
| Nature |
Científica |
| JCR Quartile |
3 |
| SJR Quartile |
3 |
| JCR Impact |
1.043 |
| Publication date |
01/11/2018 |
| ISI |
000449030500004 |
| DOI |
10.1016/j.rce.2018.04.016 |
| Abstract |
Objective: Acute interstitial pneumonia (AIP) is a severe disease of unknown etiology. Pneumocystis jirovecii is an atypical opportunistic fungus able to colonize patients with chronic pulmonary disease and inducing alveolar macrophage activation. The aim of this study was to evaluate the possible association between Pneumocystis jirovecii and AIP.\n Subjects and methods: The presence of P jirovecii in bronchoalveolar lavage fluid in the four confirmed cases of AIP identified in a tertiary-care hospital over a period of nine years was studied using a 2-step nested-PCR protocol assay.\n Results: P jirovecii was identified in the four cases. None of them had HIV infection. Two of the patients were treated empirically with trimethoprim-sulfamethoxazole, the only survivor was being one of them.\n Conclusions: Our data suggest that Pneumocystis could trigger or favor the development of AIR Further studies are needed to evaluate the role of the pathogen in the physiopathology of this disease. (C) 2018 Elsevier Espana, S.L.U. and Sociedad Espanola de Medicina Interna (SEMI). All rights reserved. |
| Keywords |
Pneumocystis jirovecii; Acute interstitial pneumonia; Polymerase chain reaction |
| Universidad Loyola members |
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