| Title | Pneumocystis jiroveci genotypes in the Spanish population |
|---|---|
| Authors | Montes-Cano, MA , DE LA HORRA PADILLA, CARMEN, Martín-Juan, J , Varela, JM , Torronteras, R , Respaldiza, N , Medrano, FJ , Calderón, EJ |
| External publication | Si |
| Means | CLINICAL INFECTIOUS DISEASES |
| Scope | Article |
| Nature | Científica |
| JCR Quartile | 1 |
| SJR Quartile | 1 |
| JCR Impact | 5.594 |
| SJR Impact | 2.301 |
| Publication date | 01/07/2004 |
| ISI | 000222087800020 |
| DOI | 10.1086/421778 |
| Abstract | This study describes the genotype distribution of Pneumocystis jiroveci in 79 respiratory samples obtained from 15 patients with acquired immunodeficiency syndrome ( AIDS) with P. jiroveci pneumonia and 64 human immunodeficiency virus-negative subjects with different chronic pulmonary diseases. The genotyping was based in analysis of 2 independent genetic loci: the mitochondrial large subunit ribosomal RNA (mt LSU rRNA) fragment ( assessed by direct sequencing) and the gene for dihydropteroate synthase ( DHPS; assessed by restriction fragment-length polymorphism). The mt LSU rRNA analysis revealed the presence of 3 different polymorphisms for both populations. The major genotype, 85C/248C, was found to be significantly higher in patients with AIDS and P. jiroveci pneumonia than in patients with pulmonary disease. The rate of genotypes 85A/248C and 85T/248C was similar in both groups. The analysis of DHPS genotypes assesses the prevalence of its 4 possible genotypes, with 35.5% of genotypes related to sulfa resistance. The data suggest a common source of infection between both groups. |
| Universidad Loyola members |
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