| Title |
Hormonal regulation of chicken intestinal NHE and SGLT-1 activities |
| Authors |
DE LA HORRA PADILLA, CARMEN, Cano, M , Peral, MJ , Calonge, ML , Ilundáin, AA |
| External publication |
Si |
| Means |
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY |
| Scope |
Article |
| Nature |
Científica |
| JCR Quartile |
2 |
| SJR Quartile |
1 |
| JCR Impact |
2.437 |
| SJR Impact |
1.191 |
| Publication date |
01/03/2001 |
| ISI |
000166917900007 |
| DOI |
10.1152/ajpregu.2001.280.3.R655 |
| Abstract |
The effects of aldosterone and arginine vasotocin (AVT) on intestinal Na+/H+ exchange (NHE) and Na+-sugar cotransport (SGLT-1) activities have been investigated using brush-border membrane vesicles isolated from Hubbard chicken small and large intestines, and they were compared with those induced by either Na+ depletion or dehydration. Na+ depletion was induced by feeding the chickens with either a low- or a high-Na+ diet for either 0.5, 1, 2, 4, or 8 days. Ileal and colonic NHE2 activity increased with the duration of the Na+ depletion, whereas that of intestinal SGLT-1 decreased, reaching a plateau after 2 days of treatment. Three-hour incubation of the intestine with aldosterone produced the same effects on NHE activity as does Na+ depletion, without altering SGLT-1 activity. However, 3-h incubation of the intestine with AVT increased intestinal SGLT-1 activity, without affecting intestinal NHE activity. It is concluded that aldosterone regulates apical ileal and colonic NHE2 activity, whereas that of SGLT-1 is regulated by AVT. |
| Keywords |
low-Na+ diet; aldosterone; arginine vasotocin; brush-border membrane vesicle; sodium/hydrogen exchange |
| Universidad Loyola members |
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