Title HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19.
Authors Castro-Santos, Patricia , Rojas-Martinez, Augusto , Riancho, José A , Lapunzina, Pablo , Flores, Carlos , Carracedo, Ángel , Díaz-Peña, Roberto , Scourge Cohort Group , Abellan, Javier , Acosta-Isaac, René , Aguado, Jose María , Aguilar, Carlos , Aguilera-Albesa, Sergio , Sabbagh, Abdolah Ahmadi , Alba, Jorge , Albu, Sergiu , Alcalá-Gallardo, Karla A M , Alcoba-Florez, Julia , Batres, Sergio Alcolea , Algarin-Lara, Holmes Rafael , Almadana, Virginia , Almeida, Julia , Almoguera, Berta , Alonso, María R , Alvarez, Nuria , Álvarez-Benítez, Yady , Álvarez-Navia, Felipe , Walther, Rodolfo Alvarez-Sala , Andreu-Bernabeu, Álvaro , Antonijoan, Maria Rosa , Arana-Arri, Eunate , Aranda, Carlos , Arango, Celso , Araque, Carolina , Araujo, Nathalia K , Araujo, Izabel M T , Arcanjo, Ana C , Arnaiz, Ana , Fernández, Francisco Arnalich , Arranz, María J , Lopez, José Ramon Arribas , Artiga, Maria-Jesus , Avello-Malaver, Yubelly , Ayuso, Carmen , Baldion, Ana María , Martín, Belén Ballina , Baptista-Rosas, Raúl C , Barranco-Díaz, Andrea , Barreda-Sánchez, María , Barrera-Penagos, Viviana , Belhassen-Garcia, Moncef , Bernal, Enrique , Bernal-Bello, David , Bezerra, Joao F , Bezerra, Marcos A C , Blanca-López, Natalia , Blancas, Rafael , Boix-Palop, Lucía , Borobia, Alberto , Bravo, Elsa , Brion, María , Brochado-Kith, Óscar , Brugada, Ramón , Bustos, Matilde , Cabello, Alfonso , Caceres-Agra, Juan J , Calbo, Esther , Calderón, Enrique J , Camacho, Shirley , Campos, Marcela C , Cañadas, Yolanda , Carbonell, Cristina , Cardona-Huerta, Servando , Carioca, Antonio Augusto F , Carpintero, Maria Sanchez , Segura, Carlos Carpio , Carratto, Thássia M T , Carrillo-Avila, José Antonio , Carvalho, Maria C C , Casasnovas, Carlos , Castano, Luis , Castaño, Carlos F , Castelao, Jose E , Candalija, Aranzazu Castellano , Castillo, María A , Ceballos, Francisco C , Chaux, Jessica G , Chaves-Santiago, Walter G , Chiquillo-Gómez, Sylena , Cid-Lopez, Marco A , Cienfuegos-Jimenez, Oscar , Conde-Vicente, Rosa , Cordero-Lorenzana, M Lourdes , Corella, Dolores , Corrales, Almudena , Cortes-Sanchez, Jose L , Corton, Marta , Costa, Tatiana X , Cruz, Raquel , Cruz, Marina S , Cuesta, Luisa , Cunha, Gabriela C R , da Silva, Gabriela V , Dalmau, David , Dantas-Komatsu, Raquel C S , Darnaude, M Teresa , de Andrés, Raimundo , de Araújo, Jéssica N G , de Juan, Carmen , De la Cruz Troca, Juan , DE LA HORRA PADILLA, CARMEN, de la Hoz, Ana B , De Martino-Rodríguez, Alba , de Sousa Alves Neri, Julianna Lys , Del Campo-Pérez, Victor , Delgado-Cuesta, Juan , Diaz-Caneja, Covadonga M , Díaz-Pérez, Anderson , de Bustamante, Aranzazu Diaz , Dietl, Beatriz , Almeida, Silvia Diz-de , do Monte Alves, Manoella , Domínguez-Garrido, Elena , Dos Santos, Katiusse A , Duarte, Alice M , Echave-Sustaeta, Jose , Eiros, Rocío , Enciso-Olivera, César O , Escudero, Gabriela , España, Pedro Pablo , Sanabria, Gladys Mercedes Estigarribia , Fariñas, María Carmen , Fernandes, Marianne R , Fernández, Ramón , Fernandez-Caballero, Lidia , Fernández-Cruz, Ana , Fernandez-Nestosa, María J , Fernández-Robelo, Uxía , Fernández-Rodríguez, Amanda , Fernández-Sampedro, Marta , Fernández-Sánchez, Ruth , Fernández-Villa, Tania , Ferrero, Silvia Fernández , Martínez, Yolanda Fernández , Capitán, Carmen Fernéndez , Flores-Pérez, Patricia , Friaza, Vicente , Fuenmayor-Hernández, Lácides , Núñez, Marta Fuertes , Fumadó, Victoria , Gadea, Ignacio , Gagliardi, Lidia , Gago-Domínguez, Manuela , Gallego, Natalia , Galoppo, Cristina , García, Inés , García, Mercedes , García, Leticia , Garcia-Cerrada, Carlos , García-de-Vicuña, Aitor , Garcia-García, Josefina , García-García, Irene , García-Ibarbia, Carmen , García-Montero, Andrés C , García-Soidán, Ana , García-Vázquez, Elisa , Torrejón, María Carmen García , Garza-Frias, Emiliano , Gentile, Angela , Gil-Fournier, Belén , Gómez-Arrue, Javier , Gómez-Duque, Mario , Carrera, Luis Gómez , García, María Gómez , Sacristán, Ángela Gómez , González-Neira, Anna , González-Peñas, Javier , Gonzalez-Sagrado, Manuel , Álvarez, Beatriz González , de Quirós, Fernan Gonzalez Bernaldo , Benito, Hugo Gonzalo , Gorgojo-Galindo, Oscar , Górgolas, Miguel , Guaragna, Florencia , Guegel, Genilson P , Guillen-Guio, Beatriz , Guillen-Navarro, Encarna , Guisado-Vasco, Pablo , Gutiérrez-Bautista, Juan F , Gutierrez-Castañeda, Luz D , Heili-Frades, Sarah , Hernandez, Estefania , Hernandez-Ortega, Luis D , Hernández-Pérez, Guillermo , Hernández-Vaquero, Rebeca , Moro, Cristina Hernández , Herraez, Belen , Herranz, M Teresa , Herrera, María , Herrero, María José , Herrero-Gonzalez, Antonio , Horcajada, Juan P , Imaz-Ayo, Natale , Intxausti-Urrutibeaskoa, Maider , Íñiguez, María , Jacomo, Rafael H , Jara, Rubén , Jazmin, Perez Maria , Jiménez, Ángel , Jiménez, Pilar , Jiménez-Alfaro, Ignacio , Jimenez-Sousa, María A , Jordan, Iolanda , Laguna-Goya, Rocío , Laorden, Daniel , Lasa-Lazaro, María , Lattig, María Claudia , Lauriente, Ailen , Borja, Anabel Liger , Llanos, Lucía , López-Bernús, Amparo , Lopez-Garcia, Esther , Lopez-Rodriguez, Rosario , López-Ruz, Miguel A , Granados, Eduardo López , Lorente, Leonardo , Lozano, José E , Lozano-Espinosa, María , Luchessi, Andre D , Mahillo, Ignacio , Mancebo, Esther , Mar, Carmen , Calvo, Cristina Marcelo , Marcos, Miguel , Marcos-Delgado, Alba , Candon, Alicia Marín , Aguilar, Pablo Mariscal , Martín, María M , Martín, María Dolores , Martín, Vicente , Martin-Fernandez, Marta , Martín-López, Caridad , Martín-Oterino, José-Ángel , Martin-Pedraza, Laura , Martín-Vicente, María , Martinez, Amalia , Martínez, Ricardo , Martínez, Juan José , Martínez, Silvia , Martínez-Aquino, Eleno , Martínez-González, Óscar , Martinez-Lopez, Iciar , Martinez-Nieto, Oscar , Martinez-Paz, Pedro , Martinez-Perez, Angel , Martínez-Ramas, Andrea , Martinez-Resendez, Michel F , Robles, Violeta Martínez , Marzal, Laura , Mazzeu, Juliana F , Medeiros, Jeane F P , Medeiros, Kelliane A , Medrano, Francisco J , Meijome, Xose M , Mejuto-Montero, Natalia , Méndez-Echevarria, Ana , Charris, Humberto Mendoza , Macías, Eleuterio Merayo , Mercadillo, Fátima , Mercado-Sesma, Arieh R , Minguez, Pablo , Molina, Antonio J J , Molina-Roldán, Elena , Montoya, Juan José , Moraes, Vitor M S , Moreira-Escriche, Patricia , Morelos-Arnedo, Xenia , Moreno-Docón, Antonio , Moreno-Escalante, Junior , Cuerda, Victor Moreno , Fernández, Alberto Moreno , Morilla, Rubén , García, Patricia Muñoz , Neira, Pablo , Nevado, Julian , Nieto-Gañán, Israel , Nunes, Joana F R , Nuñez-Torres, Rocio , Obrador-Hevia, Antònia , Ocejo-Vinyals, J Gonzalo , Olivar, Virginia , Oliveira, Silviene F , Ondo, Lorena , Orfao, Alberto , Ortega, Luis , Ortega-Paino, Eva , Ortiz-Flores, Fernando , Ortiz-Lopez, Rocio , Oteo, José A , Pachajoa, Harry , Pacheco, Manuel , Pacheco-Miranda, Fredy Javier , Conejo, Irene Padilla , Panadero-Fajardo, Sonia , Parellada, Mara , Pariente-Rodríguez, Roberto , Paz-Artal, Estela , Peces-Barba, Germán , Pedromingo Kus, Miguel S , Perales, Celia , Perez, Patricia , Pérez, César , Perez-de-Nanclares, Gustavo , Pérez-García, Felipe , Pérez-Matute, Patricia , Pérez-Serra, Alexandra , Pérez-Tomás, M Elena , Perucho, Teresa , Pichardo, Lisbeth A , Pinho, Susana M T , Pinsach-Abuin, Mellina , Pinzón, Luz Adriana , Pita, Guillermo , Pla-Junca, Francesc , Planas-Serra, Laura , Pompa-Mera, Ericka N , Porras-Hurtado, Gloria L , Pujol, Aurora , Chávez, María Eugenia Quevedo , Quijada, Maria Angeles , Quintela, Inés , Ramirez-Montaño, Diana , León, Soraya Ramiro , Sedes, Pedro Rascado , Recalde, Delia , Recio-Fernández, Emma , Resino, Salvador , Ribeiro, Adriana P , Rivadeneira-Chamorro, Carlos S , Roa-Agudelo, Diana , Pardo, Montserrat Robelo , Rodriguez, Marilyn Johanna , Rodriguez-Artalejo, Fernando , Rodríguez-Ferrer, Marena , Rodriguez-Gallego, Carlos , Rodriguez-Garcia, José A , Rodriguez-Hernandez, María A , Rodriguez-Nicolas, Antonio , Rodriguez-Palmero, Agustí , Rodríguez-Ruiz, Emilio , Rodriguez-Urrego, Paula A , Maya, Belén Rodríguez , Novoa, German Ezequiel Rodriguez , Rojo, Federico , Romero-Coronado, Andrea , García, Filomeno Rondón , Rosa, Lidia S , Rosales-Castillo, Antonio , Rubio, Cladelis , Olivera, María Rubio , Ruiz, Montserrat , Ruiz-Cabello, Francisco , Ruiz-Casares, Eva , Ruiz-Cubillan, Juan J , Ruiz-Hornillos, Javier , Ryan, Pablo , Salamanca, Hector D , Salazar-García, Lorena , Origlia, Giorgina Gabriela Salgueiro , Sánchez, Pedro-Luis , Sánchez-Pablo, Clara , Sánchez-Pernaute, Olga , Sánchez López, Antonio J , Prados, María Concepción Sánchez , Real, Javier Sánchez , Redondo, Jorge Sánchez , Sancho-Sainz, Cristina , Sangil, Anna , Santos, Arnoldo , Santos, Ney P C , Schlüter, Agatha , Segovia, Sonia , Serra-Llovich, Alex , Puras, Fernando Sevil , Porras, Marta Sevilla , Sicolo, Miguel A , Silbiger, Vivian N , Silva, Nayara S , Silva, Fabiola T C , Fuentes, Cristina Silván , Solé-Violán, Jordi , Soria, José Manuel , Sorlí, Jose V , Sousa, Renata R , Souto, Juan Carlos , Souza, Karla S C , Souza, Vanessa S , Sprockel, John J , Suárez-Rama, José Javier , Suarez-Zamora, David A , Taboada-Fraga, Xiana , Tamayo, Eduardo , Tamayo-Velasco, Alvaro , Taracido-Fernandez, Juan Carlos , Tavares, Nathali A C , Tellería, Carlos , Castaño, Jair Antonio Tenorio , Teper, Alejandro , Torres-Macho, Juan , Torres-Tobar, Lilian , Torres Gutiérrez, Ronald P , Troya, Jesús , Urioste, Miguel , Valencia-Ramos, Juan , Valido, Agustín , Gallo, Juan Pablo Vargas , Varón, Belén , Vasconcelos, Romero H T , Vega, Tomas , Velasco-Quirce, Santiago , Vélez-Santamaría, Valentina , Víctor, Virginia , Estévez, Julia Vidán , Vieitez-Santiago, Miriam , Vilches, Carlos , Villalobos, Lavinia , Villar, Felipe , Villar-Garcia, Judit , Villaverde, Cristina , Villoslada-Blanco, Pablo , Virseda-Berdices, Ana , Yáñez, Zuleima , Zapatero-Gaviria, Antonio , Zarate, Ruth , Zazo, Sandra , de Heredia, Miguel López , Mendes, Ingrid , Moreno, Rocío , Sande, Esther
External publication Si
Means HLA
Scope Article
Nature Científica
JCR Quartile 1
SJR Quartile 4
SJR Impact 0.305
Publication date 01/12/2023
DOI 10.1111/tan.15160
Abstract We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75-0.95], p = 0.024, OR = 0.86, 95% CI = [0.78-0.95], respectively). We also found the alleles HLA-A*11:01 and HLA-C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04-1.31], p = 0.045, OR = 1.14, 95% CI = [1.05-1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19.
Keywords COVID-19; HLA evolutionary divergence; HLA-A*11:01; HLA-C*04:01; SARS-CoV-2; immunogenetics
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