| Title | High Prevalence of Pneumocystis jiroveci Colonization Among Young HIV-Infected Patients |
|---|---|
| Authors | Gutierrez, Sonia , Morilla, Ruben , Leon, Juan A. , Martin-Garrido, Isabel , Rivero, Laura , Friaza, Vicente , Respaldiza, Nieves , Montes-Cano, Marcos A. , Teran, Rafael , DE LA HORRA PADILLA, CARMEN |
| External publication | Si |
| Means | JOURNAL OF ADOLESCENT HEALTH |
| Scope | Article |
| Nature | Científica |
| JCR Quartile | 1 |
| SJR Quartile | 1 |
| SJR Impact | 1.748 |
| Publication date | 01/01/2011 |
| ISI | 000285629200018 |
| DOI | 10.1016/j.jadohealth.2010.05.013 |
| Abstract | Background: Pneumocystis colonization in young HIV-infected patients has been poorly studied. The aim of this study was to analyze the prevalence of P jiroveci colonization in a cohort of young HIV-infected patients.\n Material and Methods: We designed a basal cross-sectional study in 20 young HIV-infected patients to determine the prevalence of P jiroveci colonization in oropharyngeal wash samples studied by nested polymerase chain reaction (PCR). Subsequently, patients were followed up during 50 weeks to observe the development of Pneumocystis pneumonia (PCP).\n Results: P jiroveci colonization was detected in eight (40%) of the 20 oropharyngeal wash samples. Genotype 85C/248C was the most frequent. After 50 weeks of follow-up, one colonized patient with advanced immunodepression developed PCP.\n Conclusions: We have found a high prevalence of P jiroveci colonization in young HIV-infected patients with a major prevalence of genotype 1 (85C/248C). Further studies are necessary to clarify if Pneumocystis colonization could be a potential risk factor of developing PCP in young HIV infected patients. (C) 2011 Society for Adolescent Health and Medicine. All rights reserved. |
| Keywords | Pneumocystis; Colonization; Pneumonia; HIV |
| Universidad Loyola members |
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