Title GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Authors Pairo-Castineira, Erola , Rawlik, Konrad , Bretherick, Andrew D , Qi, Ting , Wu, Yang , Nassiri, Isar , McConkey, Glenn A , Zechner, Marie , Klaric, Lucija , Griffiths, Fiona , Oosthuyzen, Wilna , Kousathanas, Athanasios , Richmond, Anne , Millar, Jonathan , Russell, Clark D , Malinauskas, Tomas , Thwaites, Ryan , Morrice, Kirstie , Keating, Sean , Maslove, David , Nichol, Alistair , Semple, Malcolm G , Knight, Julian , Shankar-Hari, Manu , Summers, Charlotte , Hinds, Charles , Horby, Peter , Ling, Lowell , McAuley, Danny , Montgomery, Hugh , Openshaw, Peter J M , Begg, Colin , Walsh, Timothy , Tenesa, Albert , Flores, Carlos , Riancho, José A , Rojas-Martinez, Augusto , Lapunzina, Pablo , GenOMICC Investigators , SCOURGE Consortium , ISARICC Investigators , 23andMe COVID-19 Team , Yang, Jian , Ponting, Chris P , Wilson, James F , Vitart, Veronique , Abedalthagafi, Malak , Luchessi, Andre D , Parra, Esteban J , Cruz, Raquel , Carracedo, Angel , Fawkes, Angie , Murphy, Lee , Rowan, Kathy , Pereira, Alexandre C , Law, Andy , Fairfax, Benjamin , Hendry, Sara Clohisey , Baillie, J Kenneth , Clohisey, Sara , Millar, Johnny , Aitkin, Emma , Aravindan, Latha , Armstrong, Ruth , Biggs, Heather , Boz, Ceilia , Brown, Adam , Chikowore, Primmy , Coutts, Audrey , Coyle, Judy , Cullum, Louise , Das, Sukamal , Day, Nicky , Donnelly, Lorna , Duncan, Esther , Finernan, Paul , Fourman, Max Head , Furlong, Anita , Furniss, James , Gallagher, Bernadette , Gilchrist, Tammy , Golightly, Ailsa , Hafezi, Katarzyna , Hamilton, Debbie , Hendry, Ross , Kearns, Naomi , Law, Dawn , Law, Rachel , Law, Sarah , Lidstone-Scott, Rebecca , Lauder, Christen , Macgillivray, Louise , Maclean, Alan , Mal, Hanning , McCafferty, Sarah , McMaster, Ellie , Meikle, Jen , Murphy, Sheena , Mybaya, Hellen , Zheng, Chenqing , Chen, Jiantao , Parkinson, Nick , Paterson, Trevor , Tucker, Petra , Schon, Katherine , Stenhouse, Andrew , Das, Mihaela , Swets, Maaike , Szoor-McElhinney, Helen , Taneski, Filip , Turtle, Lance , Wackett, Tony , Ward, Mairi , Weaver, Jane , Wrobel, Nicola , Pan, Jacqueline , Grau, Neus , Jones, Tim Owen , Lim, Rosario , Marotti, Martina , Whitton, Christopher , Bociek, Aneta , Campos, Sara , Arbane, Gill , Ostermann, Marlies , Cha, Mina , DAmato, Fabiola , Kosifidou, Eirini , Lorah, Shelley , Morera, Kyma , Bircham, Sarah , Brady, Laura , Hugill, Keith , Henning, Jeremy , Bonner, Stephen , Headlam, Evie , Jones, Jessica , List, Abigail , Morley, Joanne , Welford, Amy , Kamangu, Bobette , Ratnakumar, Anitha , Shoremekun, Abiola , Alldis, Zoe , Astin-Chamberlain, Raine , Bibi, Fatima , Biddle, Jack , Blow, Sarah , Bolton, Matthew , Borra, Catherine , Bowles, Ruth , Burton, Maudrian , Choudhury, Yasmin , Cox, Amber , Ebano, Patrizia , Fotiadis, Stavros , Gurasashvili, Jana , Halls, Rosslyn , Hartridge, Pippa , Kallon, Delordson , Kassam, Jamila , Lancoma-Malcolm, Ivone , Matharu, Maninderpal , May, Peter , Mitchelmore, Oliver , Newman, Tabitha , Patel, Mital , Pheby, Jane , Pinzuti, Irene , Prime, Zoe , Prysyazhna, Oleksandra , Shiel, Julian , Taylor, Melanie , Tierney, Carey , Zongo, Olivier , Wood, Suzanne , Zak, Anne , Collier, David , Mundy, Manuela , Thompson, Christopher , Pritchard, Lisa , Gellamucho, Minnie , Cartlidge, David , Bandla, Nageswar , Bailey, Lucy , Delaney, Jane , Scott, Leanne , Abdelrazik, Marwa , Alasdair, Frater , Carter, David , Elhassan, Munzir , Ganesan, Arunkumar , Jenkins, Samuel , Lamond, Zoe , Purohit, Dharam , Rohit, Kumar , Saleem, Malik , Wall, Alanna , Xavier, Kugan , Bakthavatsalam, Dhanalaksmi , Gehad, Kirolos , Gnanapragasam, Pakeerathan , Jain, Kapil , Jain, Swati , Malik, Abdul , Pappachan, Naveen , Moreno-Cuesta, Jeronimo , Haldeos, Anne , Vincent, Rachel , Oziegb, Maryjane , Cavazza, Anna , Cockrell, Maeve , Corcoran, Eleanor , Depante, Maria , Finney, Clare , Jerome, Ellen , Knighton, Abigail , Nayak, Monalisa , Pappa, Evita , Saha, Rohit , Saha, Sian , Dodd, Andrew , O'Reilly, Kevin , McPhail, Mark , Clarey, Emma , Noble, Harriet , Smith, John , Coghlan, Phoebe , Brett, Stephen , Gordon, Anthony , Templeton, Maie , Antcliffe, David , Banach, Dorota , Darnell, Sarah , Fernandez, Ziortza , Jepson, Eleanor , Mohammed, Amal , Rojo, Roceld , Arias, Sonia Sousa , Gurung, Anita Tamang , Wong, Jenny , Fernandez-Roman, Jaime , Hamilton, David O , Johnson, Emily , Johnston, Brian , Martinez, Maria Lopez , Mulla, Suleman , Waite, Alicia A C , Williams, Karen , Waugh, Victoria , Welters, Ingeborg , Emblem, Jessica , Norris, Maria , Shaw, David , Bashyal, Archana , Beer, Sally , Hutton, Paula , McKechnie, Stuart , Davidson, Neil , Mathew, Soya , Readion, Grace , Ryu, Jung , Wilson, Jean , Agrawal, Shruti , Elston, Kay , Jones, Megan , Meaney, Eoghan , Polgarova, Petra , Elbehery, Muhammad , Daubney, Esther , Ng, Anthony , Marshall, Jocelyn , Pathan, Nazima , Stroud, Katerina , White, Deborah , Andrew, Angela , Ashraf, Saima , Clark, Amy , Dent, Martin , Langley, Margaret , Peters, Cecilia , Ryan, Lucy , Sampson, Julia , Wei, Shuying , Baddeley, Alice , Meredith, Megan , Morris, Lucy , Gibbons, Alexandra , McLoughlin, Lisa , Delgado, Carlos Castro , Clark, Victoria , Dawson, Deborah , Ding, Lijun , Durrant, Georgia , Ezeobu, Obiageri , Harrison, Abiola , Hurt, William James , Kanu, Rebecca , Kinch, Ashley , Leaver, Susannah , Lisboa, Ana , Mathew, Jisha , Patel, Kamal , Saluzzio, Romina Pepermans , Rawlins, John , Samakomva, Tinashe , Shah, Nirav , Sicat, Christine , Texeira, Joana , De Queiroz, Joana Gomes , Da Gloria, Edna Fernandes , Maccacari, Elena , Yun, Nikki , Manna, Soumendu , Farnell-Ward, Sarah , Maizcordoba, Maria , Thanasi, Maria , Ali, Hawakin Haji , Hastings, Janice , Grauslyte, Lina , Hussain, Musarat , Ruge, Bobby , King, Sam , Pogreban, Tatiana , Rosaroso, Lace , Smith, Helen , Phull, Mandeep-Kaur , Adams, Nikkita , Franke, George , George, Aparna , Salciute, Erika , Wong, Joanna , Dunne, Karen , Flower, Luke , Sharland, Emma , Sra, Sukhmani , Andrew, Gillian , Callaghan, Marie , Barclay, Lucy , Baillie, Kenneth , Doverman, Katerine , Hope, Dave , Mcculloch, Corrienne , Fernandez, Rita , Allen, Meryem , Baptista, David , Crowe, Rebecca , Fox, Jonathan , Khera, Jacyntha , Loveridge, Adam , McKenley, India , Morino, Eriko , Naranjo, Andres , O'Connor, Denise , Simms, Richard , Sollesta, Kathryn , Swain, Andrew , Herdman-Grant, Rosie , Joseph, Anna , Nown, Angela , Rose, Steve , Pogson, David , Boxall, Helen , Brimfield, Lutece , Claridge, Helen , Daly, Zoe , George, Shenu , Gribbin, Andrew , Cheema, Yusuf , Cutler, Sean , Richards, Owen , Roynon-Reed, Anna , Cherian, Shiney , Heron, Anne Emma , Williams, Gemma , Szakmany, Tamas , Waters, Abby , Collins, Kim , Dunhill, Jill , Jones, Ffion , Morris, Rebecca , Ship, Lucy , Cardwell, Amy , Ali, Syamlan , Bhatterjee, Ravi , Bolton, Rachel , Chukkambotla, Srikanth , Coleman, Dabheoc , Dalziel, Jack , Dykes, Joseph , Fine, Christopher , Gay, Bethan , Goddard, Wendy , Goodchild, Drew , Harling, Rhiannan , Hijazi, Muhammad , Keith, Sarah , Khan, Meherunnisa , Matt, Roseanna , Ryan-Smith, Janet , Saad, Samuel , Springle, Philippa , Thomas, Jacqueline , Truman, Nick , Kazi, Aayesha , Smith, Matthew , Collier, Heather , Davison, Chloe , Duberley, Stephen , Hargreaves, Jeanette , Hartley, Janice , Patel, Tahera , Smith, Ellen , Kent, Alissa , Goodwin, Emma , Zaki, Ahmed , Tibke, Clare , Hopkins, Susan , Gerrard, Hywel , Jackson, Matthew , Bennett, Sara , Marsh, Liane , Mills, Rebecca , Bell, Jessica , Campbell, Helen , Dawson, Angela , Dodds, Steve , Duffy, Stacey , Gallagher, Lisa , McCafferty, Gemma , Short, Stacey , Smith, Tracy , Thomas, Kirsty , Walker, Claire , Reynolds, Jessica , Yates, Bryan , McKie, Hayley , Panteli, Maria , Thompson, Maria , Waddell, Gail , De Beger, Sarah , Abraheem, Azmerelda , Dunmore, Charlie , Girach, Rumanah , Jones, Rhianna , London, Emily , Nagra, Imrun , Nasir, Farah , Sainsbury, Hannah , Smedley, Clare , Brearey, Stephen , Burchett, Caroline , Faulkner, Maria , Jeffrey, Helen , Bamford, Peter , Shaikh, Firdaus , Slack, Lauren , Davies, Angela , Brooke, Hollie , Suarez, Jose Cebrian , Charlesworth, Ruth , Hansson, Karen , Norris, John , Poole, Alice , Sandhu, Rajdeep , Smithson, Elizabeth , Thirumaran, Muthu , Wagstaff, Veronica , Buckley, Sarah , Sloan, Brendan , Rose, Alastair , Major, Amy , Metcalfe, Alexandra , Almaden-Boyle, Christine , Austin, Pauline , Chapman, Susan , Eros, Alexandre , Cabrelli, Louise , Cole, Stephen , Whyte, Clare , Casey, Matt , Bafitis, Vasileios , Tsinaslanidis, George , George, Cassandra , Khade, Reena , Black, Christopher , Ashok, Sundar Raj , Farley, Sean , Brinkworth, Elaine , Harford, Rachel , Murphy, Carl , Williams, Marie , Newey, Luke , Toghill, Hannah , Lewis, Sophie , Rees, Tabitha , Battle, Ceri , Baker, Mark , Travers, Jenny , Chesters, Karen , Baxter, Nicola , Arnott, Andrew , McCreath, Gordan , McParland, Christopher , Rooney, Laura , Sim, Malcolm , Henderson, Steven , Dalton, Carol , Kennedy-Hay, Sophie , O'Donohoe, Lynn , O'Hare, Megan , Orlikowska, Izabela , McNeela, Fiona , Lyle, Amanda , Hughes, Alistair , Radhakrishnan, Jayachandran , Gibson, Sian , Bancroft, Hollie , Bellamy, Mary , Daglish, Jacqueline , Kadiri, Salma , Moore, Faye , Rhodes, Joanne , Sangombe, Mirriam , Peterkin, Zhane , Carmody, Margaret , Cottle, Juliet , Peasgood, Emily , de Gordoa, Laura Ortiz-Ruiz , Cinquina, Zoe , Howard, Kate , Joy, Rosie , Roche, Samantha , Birkinshaw, Isobel , Carter, Joseph , Ingham, Jo , Marshall, Nicola , Pearson, Harriet , Scott, Zoe , Dasgin, Jo , Gill, Jaspret , Nilsson, Annette , Bamford, Amy , Hull, Diana , Ahmadhaider, Nafeesah , Bates, Michelle , McGhee, Christopher , Ellis, Hannah , Howe, Gwenllian Sera , Singh, Jayaprakash , Stroud, Natalie , Lynch, Ceri , Krishnamurthy, Vinodh , Lim, Lai , Jha, Rajeev , Egan, Jasmine , Felton, Timothy , Glasgow, Susannah , Padden, Grace , Choudhr, Ozerah , Moss, Stuart , Lingeswaran, Saejohn , Alexander, Peter , Fiouni, Sofia , Ward, Luke , Allen, Schvearn , Shaw, Jane , Smith, Christopher , Adanini, Oluronke , Collins, Rebecca , Msiska, Maines , Ofori, Linda , Bhatia, Nikhil , Dolan, Hayley , Brunton, Mark , Caterson, Jess , Coles, Holly , Keating, Liza , Tilney, Emma , Jacques, Nicola , Frise, Matthew , Armistead, Jennifer , Bartley, Shauna , Bhuie, Parminder , Rai, Sabi , Tomkova, Gabriela , Greer, Sandra , Shuker, Karen , Tridente, Ascanio , Dobson, Emma , Hunt, Jodie , Tully, Redmond , Dearden, Joy , Drummond, Andrew , Kamath, Prakash , Mulcahy, Michelle , Munt, Shelia , O'Connor, Grainne , Philbin, Jennifer , Rishton, Chloe , Scott, Chloe , Winnard, Sarah , Hasni, Nurkamalia , Gascoyne, Rachel , Hawes, Joanne , Pritchard, Kelly , Stevenson, Lesley , Whileman, Amanda , Beavis, Sarah , Bishop, Lauren , Cart, Cindy , Dale, Katie , Kelly-Baxter, Mary , Mendelski, Adam , Moakes, Emma , Smith, Rheanna , Woodward, Jan , Wright, Stephanie , Allan, Angela , Botello, Adriana , Liew, Jade , Medhora, Jasmine , Trumper, Erin , Savage, Felicity , Scott, Teresa , Place, Marc , Kaye, Callum , Benyon, Sarah , Marriott, Suzie , Park, Linda , Quinn, Helen , Skyes, Daisy , Zitter, Lily , Baines, Kizzy , Gordon, Elizabeth , Keenan, Samantha , Pitt, Andrew , Duffy, Katharine , Ireland, Jane , Semple, Gary , Turner, Lynne , Cathcart, Susanne , Rimmer, Dominic , Puxty, Alex , Puxty, Kathryn , Hurst, Andrew , Miller, Jennifer , Speirs, Susan , Bradshaw, Zena , Brown, Joanna , Melling, Sarah , Preston, Stephen , Slawson, Nicola , Warden, Scott , Beasley, Alanna , Stoddard, Emma , Benham, Leonie , Cupitt, Jason , Caswell, Melanie , Elawamy, Lisa , Wignall, Ashleigh , Roberts, Belinda , Golding, Hannah , Leggett, Samantha , Male, Michelle , Marani, Martyna , Prager, Kirsty , Williams, Toran , Golder, Kim , Jones, Oliver , Cusack, Rebecca , Bolger, Clare , Burnish, Rachel , Carter, Michael , Jackson, Susan , Salmon, Karen , Biss, Jonathan , Aquino, Maia , Croft, Maria , Frost, Victoria , White, Ian , Govender, Keshnie , Webb, Natasha , Stapleton, Liana , Wells, Colin , Nikitas, Nikitas , Sanchez-Rodriguez, Ana , Spencer, Kayleigh , Stowe, Bethan , Izzard, Yvonne , Poole, Michelle , Monnery, Sonja , Trotman, Sallyanne , Beech, Valerie , Combes, Edward , Joefield, Teishel , Covernton, Patrick , Savage, Sarah , Woodward, Elizabeth , Camsooksai, Julie , Reschreiter, Henrik , Barclay, Charlotte , DeAth, Yasmin , Dube, Judith , Humphrey, Charlotte , Jenkins, Sarah , Langridge, Emma , Milne, Rebecca , Wadams, Beverley , Woolcock, Megan , Brett, Michael , Digby, Brian , Gemmell, Lisa , Hornsby, James , MacGoey, Patrick , O'Neil, Pauline , Price, Richard , Sundaram, Radha , Abel, Lynn , Rodden, Natalie , Thomson, Nicola , Rooney, Kevin , Currie, Susan , Parker, Natasha , Walker, Lauren , Henderson, Philip , Ogg, Bethan , Whiteley, Simon , Wilby, Liz , Long, Kate , Matthew, Shailamma , Salada, Sheila , Trott, Susan , Watts, Sarah , Friar, Zoe , Speight, Abigail , Bastion, Victoria , Chandna, Humza , Djeugam, Brice , Haseeb, Muhammad , Kent, Harriet , Lubimbi, Gamu , Murdoch, Sophie , Thomas, Alastair , David, Beena , Lorusso, Rachel , Vochin, Ana , Penacerrada, Melchizedek , Wulandari, Retno , Heath, Charlotte , Jakkula, Srinivas , Morris, Anna , Ahmed, Ashar , Nune, Arvind , Buttriss, Claire , Whitaker, Emma , Davey, Miriam , Golden, David , Acklery, Amy , Fernandes, Fabio , Seaman, Bec , Earl, Victoria , Collins, Amy , Adam, Rachel , Treus, Estefania , Holland, Sarah , Alfonso, Jordan , Bruce, Michelle , Durrans, Laura Jayne , Eltayeb, Ayaa , Hey, Samuel , Hruska, Martin , Lamb, Thomas , Rothwell, Joanne , Fitzgerald, Adele , Lindergard, Gabriella , T-Michael, Helen , Duncan, Tracey , Baxter-Dore, Sharon , Cooper, Lisa , Fox, Claire , Guerin, Jacinta , Hodgkiss, Tracey , Connolly, Karen , McAlinden, Paul , Bridgett, Victoria , Fearby, Maggie , Gulati, A , Hanson, Helen , Kelly, Sinead , McCormack, Louise , Nixon, Rachel , Robinson, Philip , Slater, Victoria , Stephenson, Elaine , Webster, Andrea , Webster, K , Hays, Carole , Hudson, Anne , Patel, Bijal , Clement, Ian , Davis, John , Francis, Sarah , Jerry, Douglas , Abernathy, Caroline , Foster, Louise , Gratrix, Andrew , Cabral-Ortega, Llucia , Hines, Matthew , Martinson, Victoria , Stones, Elizabeth , Winter, Karen , Barrow, Esther , Wylie, Katharine , Baines, Deborah , Birchall, Katie , Kolakaluri, Laurel , Clark, Richard , Sukumaran, Anila , Brandwood, Craig , Barker, Melanie , Paripoorani, Deborah , Smith, Lara , Taylor, Charlotte , Downes, Charlotte , Hayman, Melanie , Riches, Katie , Daniel, Priya , Subramanian, Deepak , Holding, Kathleen , Hilton, Mary , McDonald, Carly , Richardson, Georgina , Halladay, Georgia , Harding, Peter , Reddy, Amie , Turner-Bone, Ian , Wilding, Laura , Parker, Robert , Lloyd, Michaela , Smith, Leanne , Kelly, Charlie , Lazo, Maria , Neal, Alan , Walton, Olivia , Melville, Julie , Naisbitt, Jay , Bullock, Emily , Joseph, Rosane , Callam, Sara , Hudig, Lisa , Keshet-Price, Jocelyn , Stammers, Katie , Convery, Karen , Randell, Georgina , Fottrell-Gould, Deirdre , Mwaura, Esther , Sutherland, Sara-Beth , Stewart, Richard , Mew, Louise , Wren, Lynn , Thrasyvoulou, Laura , Willis, Heather , Scriven, James , Hopkins, Bridget , Lenton, Daniel , Roberts, Abigail , Bokhari, Maria , Lucas, Rachael , McCormick, Wendy , Ritzema, Jenny , Linnett, Vanessa , Sanderson, Amanda , Wild, Helen , Flanagan, Rebecca , Hull, Robert , Rhead, Kat , McKenna, Emma , Hughes, Gareth , Anderson, Jennifer , Jones, Kelly , Latham, Scott , Riley, Heather , Coulding, Martina , Clark, Martyn , McCormick, Jacqueline , Mercer, Oliver , Potla, Darsh , Rehman, Hafiz , Savill, Heather , Turner, Victoria , Jude, Edward , Kilroy, Susan , Apetri, Elena , Basikolo, Cathrine , Blackledge, Bethan , Catlow, Laura , Collis, Matthew , Doonan, Reece , Harris, Jade , Harvey, Alice , Knowles, Karen , Lee, Stephanie , Lomas, Diane , Lyons, Chloe , McMorrow, Liam , Michael, Angiy , Pendlebury, Jessica , Perez, Jane , Poulaka, Maria , Proudfoot, Nicola , Slevin, Kathryn , Thomas, Vicky , Walker, Danielle , Dark, Paul , Charles, Bethan , McLaughlan, Danielle , Slaughter, Melanie , Horner, Dan , Cawley, Kathryn , Marsden, Tracy , Andrews, Joyann , Beech, Emily , Akinkugbe, Olugbenga , Bamford, Alasdair , Belfield, Holly , Jones, Gareth A L , McHugh, Tara , Meghari, Hamza , Ray, Samiran , Tomas, Ana Luisa , O'Neill, Lauran , Peters, Mark , Bell, Michael , Benkenstein, Sarah , Chisholm, Catherine , Davies, Charlene , Kupiec, Klaudia , Payne, Caroline , Halls, Joanna , Blakemore, Hayley , Goff, Elizabeth , Hayes, Kati , Smith, Kerry , Stephens, Deanna , Worner, Ruth , Borislavova, Borislava , Faulkner, Beverley , Thomas, Matt , Cookson, Ruth , Gendall, Emma , Larman, Georgina , Pope, Rebecca , Smalira, Artur , Priestley, Victoria , Cosier, Tracey , Millen, Gemma , Rand, James , Schumacher, Natasha , Sandhar, Roxana , Weston, Heather , Richardson, Neil , Cooper, Lucy , Jones, Cathy , Huang, Ya-Wen Jessica , Jacob, Reni , Denmade, Craig , McIntyre, Lewis , Trodd, Dawn , Martin, Jane , Watson, Geoff , Bevan, Emily , Wreybrown, Caroline , Bano, Shereen , Bellwood, Ruth , Bentley, Michael , Bromley, Matt , Gurr, Lucy , Ledgard, Camilla , McGowan, Janet , Pye, Kate , Sellick, Kirsten , Stacey, Amelia , Warren, Deborah , Wilkinson, Brian , Akeroyd, Louise , Shafique, Huma , Morgan, James , Shorter, Susan , Swinger, Rachel , Waters, Emily , Lawton, Tom , Allan, Elizabeth , Darlington, Kate , Davies, Ffyon , Davies, Llinos , Easton, Jack , Kumar, Sumit , Lean, Richard , Mackay, Callum , Pugh, Richard , Qiu, Xinyi , Rees, Stephanie , Scanlon, Jeremy , Lewis, Joanne , Menzies, Daniel , Bolger, Annette , Davies, Gwyneth , Davies, Jennifer , Garrod, Esther , Jones, Helen , Manley, Rachel , Williams, Hannah , Frankham, Jordan , Pitts, Sally , White, Nigel , Branney, Debbie , Tiller, Heather , Efford, Georgia , Garland, Zoe , Grimmer, Lisa , Gumbrill, Bethany , Johnson, Rebekah , Sweet, Katie , Bewley, Jeremy , Coleman, Christina , Corcoran, Katie , Morano, Eva Maria Hernandez , Shiel, Rachel , Webster, Denise , Bonnici, Josephine , Daniel, Eleanor , Dell, Abbie , Kent, Melanie , Wilkinson, Ami , Brown, Ellen , Kay, Andrea , Campbell, Suzanne , Cowton, Amanda , Greenaway, Vicki , Potts, Kathryn , Hutton, Clare , Shepperson, Andrew , Forsey, Miranda , Vertue, Mark , Riches, Joanne , Kaliappan, Agilan , Nicholson, Anne , MacCallum, Niall , Bercades, Georgia , Hass, Ingrid , Martir, Gladys , Reyes, Anna , Smyth, Deborah , Zapatamartinez, Maria , Alvaro, Ana , Jetha, Champa , Ma, Louise , Booker, Lauren , Mostoles, Loreta , Pratley, Anezka , Altabaibeh, Abdelhakim , Parmar, Chetan , Gilbert, Kayleigh , Ferguson, Susie , Shepherd, Amy , Morris, Sheila , Singleton, Jo , Baruah, Rosie , Amamio, Maria , Birch, Sophie , Briton, Kate , Clark, Sarah , Doverman, Katherine , Marshall, Lucy , Simpson, Scott , Lloyd, Georgina , Bell, Stephanie , Rivers, Vanessa , Purewal, Bally , Hammerton, Kate , Anderson, Susan , Birch, Janine , Collins, Emma , Oleary, Ryan , Cornell, Sarah , Jarmain, Jordan , Rogerson, Kimberley , Wakinshaw, Fiona , Woods, Lindsey , Rostron, Anthony , Elcioglu, Zeynep , Roy, Alistair , Bell, Gillian , Dickson, Holly , Wilcox, Louise , Katary, Amro , English, Katy , Hutter, Joanne , Pawley, Corinne , Doble, Patricia , Shovelton, Charmaine , Vaida, Marius , Purnell, Rebecca , Thomas, Ashly , Cagova, Lenka , Fofano, Adama , Holcombe, Helen , Mitchell, Alice Michael , Mwaura, Lucy , Raman, Krithivasan P , Garnr, Lucie , Mepham, Sue , Paques, Kitty , Vuylsteke, Alain , Mackie, Jennifer , Pearn, Carmen , Zamikula, Julie , Birt, Mark , Gude, Estefania Treus , Nyirenda, Maggie , Capozzi, Lisa , Reece-Anthony, Rosie , Khaliq, Waqas , Noor, Hazma , Nilo, Alfa Cresia , Grove, Michelle , Daniel, Amelia , Finn, Joanne , White, Nikki , Saha, Rajnish , Badal, Bibi , Ixer, Karen , Duffin, Donna , Player, Ben , Hill, Helen , Cole, Jade , Brooks, Jenny , Davies, Michelle , Davies, Rhys , Hunt, Lauren , Thomas, Emma , Williams, Angharad , Oblak, Metod , Thankachen, Mini , Irisari, Jamie , Sayan, Amrinder , Popescu, Monica , Finch, Cheryl , Jamieson, Andrew , Quinn, Alison , Cooper, Joshua , Liderth, Sarah , Waddington, Natalia , Burn, Iona , Manso, Katarina , Penn, Ruth , Tebbutt, Julie , Thornton, Danielle , Winchester, James , Hambrook, Geraldine , Shanmugasundaram, Pradeep , Craig, Jayne , Simpson, Kerry , Sibbett, Louise , Paine, Sheila , Reed, Annabel , Conyngham, Jo-Anna , Mupudzi, McDonald , Thomas, Rachel , Wright, Mary , Griffin, Denise , Partridge, Richard , Corral, Maria Alvarez , Muchenje, Nycola , Sitonik, Mildred , Brown, Caroline Wrey , Butler, Aaron , Folkes, Linda , Fox, Heather , Gardner, Amy , Helm, David , Hobden, Gillian , King, Kirsten , Margalef, Jordi , Margarson, Michael , Martindale, Tim , Meadows, Emma , Raynard, Dana , Thirlwall, Yvette , Baird, Yolanda , Gomez, Raquel , Martin, Darren , Hodgson, Luke , Corin, Clinton , Sidall, Erikka , Szabo, Densie , Floyd, Sharon , Davies, Hannah , Austin, Karen , Kelsall, Olivia , Wood, Hannah , Anderson, Peter , Archer, Katie , Burtenshaw, Andrew , Clayton, Sarah , Cother, Naiara , Cowley, Nicholas , Davis, Caroline , Digby, Stephen , Durie, Alison , Harrison, Alison , Low, Emma , McAlindon, Michael , McCurdy, Alex , Morgan, Aled , Rankin, Tobias , Thrush, Jessica , Tranter, Helen , Vigurs, Charlie , Wild, Laura , Cornell, Thomas , Ralph, Kate , Bean, Sarah , Burt, Karen , Spivey, Michael , Richards, Carol , Tedstone, Rachel , Carmody, Siobhain , Zhao, Xiaobei , Page, Valerie , Guanco, Mark Louie , Hoxha, Elvira , Zorloni, Camilla , Dean, Charlotte , Jones, Emma , Carter, Emma , Dunn, Joshua , Kong, Thomas , Mahenthran, Mervin , Marsh, Chris , Holland, Maureen , Keenan, Natalie , Mahmoud, Mohamed , Lyons, Marc , Bradley-Potts, Joanne , Wassall, Helen , Young, Meghan , Bradley, Paul , Burda, Dorota , Donlon, Sinead , Harden, Lesley , Harris, Celia , Mayangao, Irving , Montaser, Rugia , Mtuwa, Sheila , Piercy, Charles , Smith, Eleanor , Stone, Sarah , Verula, Jerik , Blackman, Helen , Marriott, Cheryl , Michalak, Natalia , Creagh-Brown, Ben , Salberg, Armorel , Boyer, Naomi , Pristopan, Veronika , Maynard, Victoria , Walker, Rachel , Hormis, Anil , Collier, Dawn , Graham, Cheryl , Maynard, Vicky , McCormick, Jake , Warrington, Jake , Cosgrove, Denise , McFarland, Denise , Ratcliffe, Judith , Charnock, Rob , Wynter, Inez , Gill, Mandy , Kirk, Jill , Paul, Paul , Ratnam, Valli , Shelton, Sarah , Jardine, Catherine , Hay, Alasdair , Williams, Dewi , Deacon, Bethan , Durga, Latha , Hibbert, Meg , Kennard-Holden, Gareth , Woodford, Chrsitopher , Pothecary, Carla , Tetla, Dariusz , Agravante, Kevin , Smeaton, Justyna , Price, Alicia , Thomas, Alice , Thorpe, Chris , Knights, Ellen , Ward, Donna , Laha, Shondipon , Verlander, Mark , Williams, Alexandra , Prout, Rachel , Langton, Helen , Watters, Malcolm , Hunt, Charlotte , Novis, Catherine , Arif, Sarwat , Cunningham, Amy , Hewitt, Claire , Hindale, Julia , Jackson-Lawrence, Karen , Shepardson, Sarah , Wills, Maryanne , Butler, Susie , Tavares, Silivia , Barber, Russell , Hilldrith, Annette , Hubbard, Kelly , Egginton, Dawn , Clark, Michele , Purvis, Sarah , Sinclair, Simon , Collins, Vicky , Landeg, Bethan , Sell, Craig , Coetzee, Samantha , Gales, Alistair , Icke, Becky , Raj, Meena , Williams, Caroline , Williams, Jill , Hill, Lucy , Kayani, Abdul , Masunda, Bridgett , Gondo, Prisca , Atayeva, Nigara , Cruz, Carina , Pattison, Natalie , Burnett, Caroline , Hatton, Jonathan , Heeney, Elaine , Newton, Maria , Al-Moasseb, Hassan , Behan, Teresa , Stead, Rachael , Mitra, Atideb , Humphreys, Sally , Cockerill, Helen , Tampsett, Ruth , Postovalova, Evgeniya , Coventry, Tina , McGregor, Amanda , Fowler, Susan , Macmahon, Mike , Cochrane, Patricia , Pirie, Sandra , Hanley, Sarah , Ali, Asifa , Brady, Megan , Dale, Sam , Dance, Annalisa , Gledhill, Lisa , Greig, Jill , Hanson, Kathryn , Holdroyd, Kelly , Home, Marie , Ishaq, Tahira , Kelly, Diane , Matapure, Lear , Melia, Deborah , Mellor, Samantha , Merwaha, Ekta , Nortcliffe, Tonicha , Shaw, Lisa , Shaw, Ryan , Wood, Tracy , Bayo, Lee-Ann , Usher, Miranda , Wilson, Alison , Kitson, Ross , Pinnell, Jez , Robinson, Matthew , Boltwood, Kaitlin , Birch, Jenny , Bough, Laura , Tutton, Rebecca , Winter-Goodwin, Barbara , Goodsell, Josie , Taylor, Kate , Williams, Patricia , Williams, Sarah , Cave, Ashleigh , Rees, James , Imeson-Wood, Janet , Smith, Jacqueline , Amin, Vishal , Karthik, Komala , Kausar, Rizwana , Anastasescu, Elena , Reid, Karen , Anumakonda, Vikram , Stoddart, Ella , Demetriou, Carrie , Eckbad, Charlotte , Howie, Lucy , Mitchard, Sarah , Ramos, Lidia , White, Katie , Hierons, Sarah , Kelly, Fiona , Serrano-Ruiz, Alfredo , Evans, Gabrielle , Nicol, Liz , Wilkins, Joy , Hulacka, Kim , Debreceni, Gabor , Crickmore, Vikki , Hill, Kay , Kannan, Thogulava , Dagutao, Zenaida , Beesley, Kate , Lewis, Alison , Perry, Jess , Antony, Sherly , Board, Sarah , Buckley, Clare , Pippard, Lucy , Tanate, Alfonso , Wood, Diane , Kubisz-Pudelko, Agnieska , Gouda, Ayman , Auld, Fiona , Donnachie, Joanne , Murdoch, Euan , Prentice, Lynn , Runciman, Nikole , Senaratne, Dhaneesha , Short, Abigail , Sweeney, Laura , Symon, Lesley , Todd, Anne , Turner, Patricia , McCann, Erin , Salutous, Dario , Edmond, Ian , Whitelaw, Lesley , Venkatesh, Harish , Bland, Yvonne , Kajtor, Istvan , Kavanagh, Lisa , Singler, Karen , Linfield-Brown, George , Moore, Luke Stephen Prockter , Vizcaychipi, Marcela , Martins, Laura , Moore, Luke , Bull, Rhian , Carungcong, Jaime , Allen, Louise , Beranova, Eva , Knight, Alicia , Price, Carly , Tilbey, Sorrell , Turney, Sharon , Hazelton, Tracy , Tutt, Gabriella , Arora, Mansi , Turki, Salah , Sinfield, Emily , Deery, Joanne , Ramos, Hazel , Cristiano, Daniele , Dormand, Natalie , Farzad, Zohreh , Gummadi, Mahitha , Salmi, Sara , Sloane, Geraldine , Varghese, Mathew , Patel, Brijesh , Kamal, Liyanage , Zborowski, Anelise Catelan , Coe, Ryan , Anderson, Madeleine , Beadle, Jane , Coates, Charlotte , Collins, Katy , Crowley, Maria , Johnson, Laura , King, Laura , Paramsothy, Remi , Sargeant, Janet , Silva, Pedro , Stuart, Carmel , Taylor, June , Tyl, David , Wakefield, Phillipa , Kamundi, Charlotte , Olufuwa, Olumide , Belagodu, Zakaulla , Gherman, Anca , Oakley, Naomi , Allan, John , Geary, Tim , Meikle, Alistair , O'Brien, Peter , Wood, Stephen , Clark, Andrew , Houston, Gordon , Black, Karen , Clarkson, Michelle , D'Sylva, Stuart , Morrison, Alan , Norman, Kathryn , Taylor, Margaret , Clements, Suzanne , Cohrane, Catriona , Gonzalez, Nora , Strachan, Dominic , Moar, Kirsten , Murphy, Lorna , Smythe, Michelle , Brickell, Kathy , Ali, Inthakab Ali Mohamed , Beaumont, Karen , Elsaadany, Mohamed , Fernandes, Kay , Ally, Sameena Mohamed , Rangarajan, Harini , Sarathy, Varun , Selvanayagam, Sivarupan , Vedage, Dave , White, Matthew , Coton, Zoe , Joshy, Aricsa , Blunt, Mark , Curgenven, Hollie , Botfield, Liam , Dexter, Catherine , Kuravi, Aditya , Butler, Joanne , Chadwick, Robert , Ranga, Poonam , Richardson, Lisa , Virgilio, Emma , Anwer, Maddiha , Garg, Atul , Botfield, Donna , Marriott, Xana , Stewart, Keely , Phillips, Claire , Nowak, Justyna , Skinner, Denise , Jones, Sian , Crawley, Rikki , Crew, Abigail , Cunningham, Mishell , Daniels, Allison , Harrison, Laura , Hope, Susan , Lancaster, Nicola , Matthews, Jamie , Wray, Gemma , Nicholson, Alice , Inweregbu, Ken , Cutts, Sarah , Miller, Katharine , Brady, Ailbhe , Chan, Rebekah , McIvor, Shane , Prady, Helena , Mathew, Bijoy , Little, Jeff , Furniss, Tim , Wright, Chris , King, Bernadette , Wasson, Christopher , O'Neill, Aisling , Turley, Christine , McGuigan, Peter , Collins, Erin , Finn, Stephanie , Green, Jackie , McAuley, Julie , Nair, Abitha , Quinn, Charlotte , Tauro, Suzanne , Ward, Kathryn , McGinlay, Michael , Reddy, Kiran , Ahmad, Norfaizan , Anderson, Samantha , Barker, Joann , Bauchmuller, Kris , Birchall, Kathryn , Bird, Sarah , Cawthron, Kay , Chetam, Luke , Cole, Joby , Donne, Ben , Foote, David , Ford, Amber , Hanratty, Helena , Harrington, Kate , Hesseldon, Lisa , Housley, Kay , Jackson, Yvonne , Jarman, Claire , Kibutu, Faith , Lenagh, Becky , Macharia, Irene , Masuko, Shamiso , Milner, Leanne , Newell, Helen , Nwafor, Lorenza , Oxspring, Simon , Phillips, Patrick , Raithatha, Ajay , Rowland-Jones, Sarah , Smith, Jacqui , Thompson, Roger , Trower, Helen , Walker, Sara , Watson, James , Wiles, Matthew , Lye, Alison , Willson, Jayne , Mills, Gary , Harris, Sansha , Hartill, Eleanor , Barron, Anthony , Collins, Ciara , Kaul, Sundeep , Nolan, Claire , Polgar, Oliver , Prendergast, Claire , Rogers, Paula , Shokkar, Rajvinder , Woodruff, Meriel , Mahay, Kanta , Thwaites, Vicky , Reed, Anna , Meyrick, Hayley , Passmore, Heather , Farwell, James , Brown, Alison , Gregory, Jane , Armstrong, Diane , Bowey, Angie , Cowley, Anne , Corner, Andrew , Highgate, Judith , Rutherfurd, Claire , Taylor, Jo-Anne , Goodwin, Sarah , Rutherford, Claire , Eapen, Beena , Trim, Fiona , Donnison, Phil , Armstrong, Lisa , Bates, Hayley , Dooks, Emma , Farquhar, Fiona , Kitching, Amy , McParland, Chantal , Packham, Sophie , Hairsine, Brigid , Patil, Anand , Andreou, Premetie , Hales, Dawn , Mathews, Megha , Patel, Rekha , Barry, Peter , Flint, Neil , Hailstone, Jessica , Ghuman, Navneet , Leonard, Bethany , Lees, Rachel , Butcher, Deborah , Leng, Katy , Butterworth-Cowin, Nicola , O'Sullivan, Susie , Ghosh, Alison , Williams, Emma , Adams, Colene , Agasou, Anita , Arden, Tracie , Beekes, Mandy , Bowes, Amy , Boyle, Pauline , Button, Heather , Carnahan, Mandy , Carter, Anne , Childs, Danielle , Gaylard, Jane , Hurford, Fran , Hussain, Yasmin , Javaid, Ayesha , Jones, James , Leigh, Michael , Martin, Terry , Millward, Helen , Motherwell, Nichola , Mullan, Dee , Newman, Julie , Rikunenko, Rachel , Stickley, Jo , Summers, Julie , Ting, Louise , Tivenan, Helen , Donaldson, Denise , Capps, Nigel , Cale, Emily , Jose, Sanal , Osbourne, Wendy , Pajak, Susie , Rankin, Jayne , Tonks, Louise , Baird, Tracy , Harkins, Margaret , Ruddy, Jim , West, Joe , Duffield, Joseph , Mallon, Lewis , Smith, Oliver , Smuts, Sara , Campbell, Andy , Davies, Cate , Davies, Sarah , Jobes, Lisa , Whitehead, Victoria , Watkins, Clare , Bowman, Fiona , Milligan, Barry , McPherson, Liane , Metherell, Stella , Harris, Nichola , Lake, Victoria , Radford, Elizabeth , Smallwood, Andy , Gopal, Shameer , Vassell, Katherine , Bell, Dina , Boyle, Rosalind , Douglas, Katie , Glass, Lynn , Lennon, Liz , Rattray, Austin , Beith, Claire , Lee, Emma , Jones, Danielle , Parsons, Penny , Attwood, Ben , Jefferson, Paul , Ranganathan, Mohan , Atwal, Inderjit , Campbell, Bridget , Day, Angela , Stagg, Camilla , Haynes, Emma , Ahmed, Cecilia , Clamp, Sarah , Colley, Julie , Haq, Risna , Hayes, Anne , Joseph, Sibet , Maqsood, Zahira , Hussain, Samia , Hulme, Jonathan , Domingos, Patience , Kumar, Rita , Purewal, Manjit , Taylor, Becky , Bunni, Lara , Latif, Monica , Jennings, Claire , Jose, Shilu , Marshall, Rebecca , Metryka, Aleksandra , Subramanian, Gayathri , Burgoyne, Adam , O'Connell, Susan , Tyler, Amanda , Waldron, Joanne , Hilltout, Paula , Evitts, Jayne , Ward, Geraldine , Bremmer, Pamela , Hawkins, Carl , Jackman, Sophie , Ogorek, Michal , Ashby, Kylie , Thornton, Lorraine , Mercer, Pauline , Halkes, Matthew , Revill, Adam , Saint, Bryony , Fletcher, Jo , Netherton, Kimberley , Chablani, Manish , Kirkby, Amy , Roper, Amanda , Szymiczek, Kinga , Sutherland, Isobel , O'Brien, Linda , Connell, Joanne , Davies, Kim , Lewis, Tracy , Omar, Zohra , Perkins, Emma , Roche, Lisa , Sathe, Sonia , Davies, Ellie , Lyon, Alex , Mapfunde, Isheunesu , Willis, Charlotte , Hitchcock, Rachael , Hall, Kathryn , King, Christopher , Fagan, Andrew , Nazari, Roonak , Worsley, Lucy , Allibone, Suzanne , Kasipandian, Vidya , Patel, Amit , Cutting, Parisa , Genetu, Roman , Mac, Ainhi , Murphy, Anthony , Ward, Sinead , Butt, Fatima , Ayers, Amanda , Harrison, Wendy , Mackintosh, Katherine , North, Julie , Ashton, Lydia , Bi, Rehana , Owen, Samantha , Winmill, Helen , Scholefield, Barney , Blowing, Hannah , Williams, Erin , Duskova, Michaela , Edwards, Michelle , Rees, Alun , Thomas, Helen , Hughes, Rachel , Brooks, Jolene , Phipps, Janet , Brooks, Suzanne , Dennis, Catherine , Srikaran, Sinduya , Sukha, Anisha , Tiongson, Gerlynn , Adams, Katie , Andrew, Benedict , Brayne, Adam , Carter, Sasha , Findlay, Louise , Fisher, Emma , Jackson, Peter , Kaye, Duncan , Parkin, Juliet , Tuckey, Victoria , Hunt, Jane , Love, Nicholas , van Koutrick, Lynne , Hanson, Ashley , Dent, Kathy , Horsley, Elizabeth , Pearson, Sandra , Spencer, Sue , Hutchinson, Dorothy
External publication Si
Means Nature
Scope Article
Nature Científica
JCR Quartile 1
SJR Quartile 1
SJR Impact 18.509
Publication date 17/05/2023
DOI 10.1038/s41586-023-06034-3
Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown(1) to be highly efficient for discovery of genetic associations(2). Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group(3). Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte-macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).
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