Title Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Authors Degenhardt, Frauke , Ellinghaus, David , Juzenas, Simonas , Lerga-Jaso, Jon , Wendorff, Mareike , Maya-Miles, Douglas , Uellendahl-Werth, Florian , ElAbd, Hesham , Ruehlemann, Malte C. , Arora, Jatin , Oezer, Onur , Lenning, Ole Bernt , Myhre, Ronny , Vadla, May Sissel , Wacker, Eike M. , Wienbrandt, Lars , Blandino Ortiz, Aaron , de Salazar, Adolfo , Garrido Chercoles, Adolfo , Palom, Adriana , Ruiz, Agustin , Garcia-Fernandez, Alba-Estela , Blanco-Grau, Albert , Mantovani, Alberto , Zanella, Alberto , Holten, Aleksander Rygh , Mayer, Alena , Bandera, Alessandra , Cherubini, Alessandro , Protti, Alessandro , Aghemo, Alessio , Gerussi, Alessio , Ramirez, Alfredo , Braun, Alice , Nebel, Almut , Barreira, Ana , Lleo, Ana , Teles, Ana , Kildal, Anders Benjamin , Biondi, Andrea , Caballero-Garralda, Andrea , Ganna, Andrea , Gori, Andrea , Glueck, Andreas , Lind, Andreas , Tanck, Anja , Hinney, Anke , Carreras Nolla, Anna , Fracanzani, Anna Ludovica , Peschuck, Anna , Cavallero, Annalisa , Dyrhol-Riise, Anne Ma , Ruello, Antonella , Julia, Antonio , Muscatello, Antonio , Pesenti, Antonio , Voza, Antonio , Rando-Segura, Ariadna , Solier, Aurora , Schmidt, Axel , Cortes, Beatriz , Mateos, Beatriz , Nafria-Jimenez, Beatriz , Schaefer, Benedikt , Jensen, Bjoern , Bellinghausen, Carla , Maj, Carlo , Ferrando, Carlos , DE LA HORRA PADILLA, CARMEN, Quereda, Carmen , Skurk, Carsten , Thibeault, Charlotte , Scollo, Chiara , Herr, Christian , Spinner, Christoph D. , Gassner, Christoph , Lange, Christoph , Hu, Cinzia , Paccapelo, Cinzia , Lehmann, Clara , Angelini, Claudio , Cappadona, Claudio , Azuure, Clinton , Bianco, Cristiana , Cea, Cristina , Sancho, Cristina , Hoff, Dag Arne Lihaug , Galimberti, Daniela , Prati, Daniele , Haschka, David , Jimenez, David , Pestana, David , Toapanta, David , Muniz-Diaz, Eduardo , Azzolini, Elena , Sandoval, Elena , Binatti, Eleonora , Scarpini, Elio , Helbig, Elisa T. , Casalone, Elisabetta , Urrechaga, Eloisa , Paraboschi, Elvezia Maria , Pontali, Emanuele , Reverter, Enric , Calderon, Enrique J. , Navas, Enrique , Solligard, Erik , Contro, Ernesto , Arana-Arri, Eunate , Aziz, Fatima , Garcia, Federico , Garcia Sanchez, Felix , Ceriotti, Ferruccio , Martinelli-Boneschi, Filippo , Peyvandi, Flora , Kurth, Florian , Blasi, Francesco , Malvestiti, Francesco , Medrano, Francisco J. , Mesonero, Francisco , Rodriguez-Frias, Francisco , Hanses, Frank , Mueller, Fredrik , Hemmrich-Stanisak, Georg , Bellani, Giacomo , Grasselli, Giacomo , Pezzoli, Gianni , Costantino, Giorgio , Albano, Giovanni , Cardamone, Giulia , Bellelli, Giuseppe , Citerio, Giuseppe , Foti, Giuseppe , Lamorte, Giuseppe , Matullo, Giuseppe , Baselli, Guido , Kurihara, Hayato , Neb, Holger , My, Ilaria , Kurth, Ingo , Hernandez, Isabel , Pink, Isabell , de Rojas, Itziar , Galvan-Femenia, Ivan , Holter, Jan Cato , Afset, Jan Egil , Heyckendorf, Jan , Kaessens, Jan , Damas, Jan Kristian , Rybniker, Jan , Altmueller, Janine , Ampuero, Javier , Martin, Javier , Erdmann, Jeanette , Banales, Jesus M. , Badia, Joan Ramon , Dopazo, Joaquin , Schneider, Jochen , Bergan, Jonas , Barretina, Jordi , Walter, Joern , Hernandez Quero, Jose , Goikoetxea, Josune , Delgado, Juan , Guerrero, Juan M. , Fazaal, Julia , Kraft, Julia , Schroeder, Julia , Risnes, Kari , Banasik, Karina , Mueller, Karl Erik , Gaede, Karoline I. , Garcia-Etxebarria, Koldo , Tonby, Kristian , Heggelund, Lars , Izquierdo-Sanchez, Laura , Bettini, Laura Rachele , Sumoy, Lauro , Sander, Leif Erik , Lippert, Lena J. , Terranova, Leonardo , Nkambule, Lindokuhle , Knopp, Lisa , Gustad, Lise Tuset , Garbarino, Lucia , Santoro, Luigi , Tellez, Luis , Roade, Luisa , Ostadreza, Mahnoosh , Intxausti, Maider , Kogevinas, Manolis , Riveiro-Barciela, Mar , Berger, Marc M. , Schaefer, Marco , Niemi, Mari E. K. , Gutierrez-Stampa, Maria A. , Carrabba, Maria , Figuera Basso, Maria E. , Valsecchi, Maria Grazia , Hernandez-Tejero, Maria , Vehreschild, Maria J. G. T. , Manunta, Maria , Acosta-Herrera, Marialbert , D'Angio, Mariella , Baldini, Marina , Cazzaniga, Marina , Grimsrud, Marit M. , Cornberg, Markus , Noethen, Markus M. , Marquie, Marta , Castoldi, Massimo , Cordioli, Mattia , Cecconi, Maurizio , D'Amato, Mauro , Augustin, Max , Tomasi, Melissa , Boada, Merce , Dreher, Michael , Seilmaier, Michael J. , Joannidis, Michael , Wittig, Michael , Mazzocco, Michela , Ciccarelli, Michele , Rodriguez-Gandia, Miguel , Bocciolone, Monica , Miozzo, Monica , Imaz Ayo, Natale , Blay, Natalia , Chueca, Natalia , Montano, Nicola , Braun, Nicole , Ludwig, Nicole , Marx, Nikolaus , Martinez, Nilda , Cornely, Oliver A. , Witzke, Oliver , Palmieri, Orazio , Faverio, Paola , Preatoni, Paoletta , Bonfanti, Paolo , Omodei, Paolo , Tentorio, Paolo , Castro, Pedro , Rodrigues, Pedro M. , Espana, Pedro Pablo , Hoffmann, Per , Rosenstiel, Philip , Schommers, Philipp , Suwalski, Phillip , de Pablo, Raul , Ferrer, Ricard , Bals, Robert , Gualtierotti, Roberta , Gallego-Duran, Rocio , Nieto, Rosa , Carpani, Rossana , Morilla, Ruben , Badalamenti, Salvatore , Haider, Sammra , Ciesek, Sandra , May, Sandra , Bombace, Sara , Marsal, Sara , Pigazzini, Sara , Klein, Sebastian , Pelusi, Serena , Wilfling, Sibylle , Bosari, Silvano , Volland, Sonja , Brunak, Soren , Raychaudhuri, Soumya , Schreiber, Stefan , Heilmann-Heimbach, Stefanie , Aliberti, Stefano , Ripke, Stephan , Dudman, Susanne , Wesse, Tanja , Zheng, Tenghao , Bahmer, Thomas , Eggermann, Thomas , Illig, Thomas , Brenner, Thorsten , Pumarola, Tomas , Feldt, Torsten , Folseraas, Trine , Gonzalez Cejudo, Trinidad , Landmesser, Ulf , Protzer, Ulrike , Hehr, Ute , Rimoldi, Valeria , Monzani, Valter , Skogen, Vegard , Keitel, Verena , Kopfnagel, Verena , Friaza, Vicente , Andrade, Victor , Moreno, Victor , Albrecht, Wolfgang , Peter, Wolfgang , Poller, Wolfgang , Farre, Xavier , Yi, Xiaoli , Wang, Xiaomin , Khodamoradi, Yascha , Karadeniz, Zehra , Latiano, Anna , Goerg, Siegfried , Bacher, Petra , Koehler, Philipp , Tran, Florian , Zoller, Heinz , Schulte, Eva C. , Heidecker, Bettina , Ludwig, Kerstin U. , Fernandez, Javier , Romero-Gomez, Manuel , Albillos, Agustin , Invernizzi, Pietro , Buti, Maria , Duga, Stefano , Bujanda, Luis , Hov, Johannes R. , Lenz, Tobias L. , Asselta, Rosanna , de Cid, Rafael , Valenti, Luca , Karlsen, Tom H. , Caceres, Mario , Franke, Andre , COVICAT study , Norwegian SARS-CoV-2 , Pa Study Group , The STORM Study grp
External publication Si
Means HUMAN MOLECULAR GENETICS
Scope Article
Nature Científica
JCR Quartile 2
SJR Quartile 1
JCR Impact 3.5
SJR Impact 1.831
Publication date 01/12/2022
ISI 000972701300001
DOI 10.1093/hmg/ddac158
Abstract Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a similar to 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
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