Title Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2.
Authors Pérez-Jurado, Luis A , Cáceres, Alejandro , Balagué-Dobón, Laura , Esko, Tonu , López de Heredia, Miguel , Quintela, Inés , Cruz, Raquel , Lapunzina, Pablo , Carracedo, Ángel , SCOURGE Cohort Group , González, Juan R , Abellán, Javier , Acosta-Isaac, René , Aguado, Jose María , Aguilar, Carlos , Aguilera-Albesa, Sergio , Ahmadi Sabbagh, Abdolah , Alba, Jorge , Albu, Sergiu , Alcalá-Gallardo, Karla A M , Alcoba-Florez, Julia , Alcolea Batres, Sergio , Algarin-Lara, Holmes Rafael , Almadana, Virginia , Medeiros, Kelliane A , Almeida, Julia , Almoguera, Berta , Alonso, María R , Álvarez, Nuria , Álvarez-Sala Walther, Rodolfo , Álvarez-Benítez, Yady , Álvarez-Navia, Felipe , Dos Santos, Katiusse A , Andreu-Bernabeu, Álvaro , Antonijoan, Maria Rosa , Martínez-Aquino, Eleno , Arana-Arri, Eunate , Aranda, Carlos , Arango, Celso , Araque, Carolina , Araujo, Nathalia K , Arcanjo, Ana C , Arnaiz, Ana , Arnalich Fernández, Francisco , Arranz, María J , Arribas López, José Ramón , Artiga, Maria-Jesús , Avello-Malaver, Yubelly , Ayuso, Carmen , Ballina Martín, Belén , Baptista-Rosas, Raúl C , Baldion, Ana María , Barranco-Díaz, Andrea , Barreda-Sánchez, María , Barrera-Penagos, Viviana , Belhassen-Garcia, Moncef , Bernal-Bello, David , Bernal, Enrique , Bezerra, Joao F , Bezerra, Marcos A C , Blanca-López, Natalia , Blancas, Rafael , Boix-Palop, Lucía , Borobia, Alberto , Bravo, Elsa , Brion, María , Brochado-Kith, Óscar , Brugada, Ramón , Bustos, Matilde , Cabello, Alfonso , Cáceres-Agra, Juan J , Calbo, Esther , Calderón, Enrique J , Camacho, Shirley , Ceballos, Francisco C , Cañadas, Yolanda , Carbonell, Cristina , Cardona-Huerta, Servando , Sánchez-Carpintero Abad, María , Carpio Segura, Carlos , Carrillo-Avila, José Antonio , Campos, Marcela C , Casasnovas, Carlos , Castaño, Luis , Castaño, Carlos F , Castelao, Jose E , Castellano Candalija, Aranzazu , Castillo, María A , Chaves-Santiago, Walter G , Chiquillo-Gómez, Sylena , Cid-López, Marco A , Cienfuegos-Jiménez, Óscar , Conde-Vicente, Rosa , Cunha, Gabriela C R , Cordero-Lorenzana, M Lourdes , Corella, Dolores , Corrales, Almudena , Cortés-Sánchez, Jose L , Corton, Marta , Souza, Karla S C , Silva, Fabiola T C , Cuesta, Luisa , Tavares, Nathali A C , Carvalho, Maria C C , Dalmau, David , Dantas-Komatsu, Raquel C S , Darnaude, M Teresa , de Andrés, Raimundo , de Juan, Carmen , de la Cruz Troca, Juan J , DE LA HORRA PADILLA, CARMEN, de la Hoz, Ana B , De Martino-Rodríguez, Alba , Cruz, Marina S , de Sousa Alves Neri, Julianna Lys , Del Campo-Pérez, Victor , Delgado-Cuesta, Juan , Diaz de Bustamante, Aranzazu , Díaz-Pérez, Anderson , Dietl, Beatriz , Diz-de Almeida, Silvia , do Monte Alves, Manoella , Domínguez-Garrido, Elena , Rosa, Lidia S , Luchessi, Andre D , Echave-Sustaeta, Jose , Eiros, Rocío , Enciso-Olivera, César O , Escudero, Gabriela , España, Pedro Pablo , Estigarribia Sanabria, Gladys , Fariñas, María Carmen , Fernández, Ramón , Fernández-Caballero, Lidia , Fernández-Cruz, Ana , Fernández-Ferrero, Silvia , Fernández Martínez, Yolanda , Fernandez-Nestosa, María J , Fernández-Robelo, Uxía , Fernández-Rodríguez, Amanda , Fernández-Sampedro, Marta , Fernández, Ruth , Fernández-Villa, Tania , Fernández-Capitán, Carmen , Carioca, Antonio Augusto F , Flores-Pérez, Patricia , Fuenmayor-Hernández, Lácides , Fuertes-Núñez, Marta , Fumadó, Victoria , Gadea, Ignacio , Gagliardi, Lidia , Gago-Domínguez, Manuela , Gallego, Natalia , Galoppo, Cristina , García-Soidán, Ana , García-Cerrada, Carlos , García-de-Vicuña, Aitor , Garcia-García, Josefina , García-García, Irene , García-Ibarbia, Carmen , García-Montero, Andrés C , García, Leticia , García, Mercedes , García Torrejón, María Carmen , García, Inés , García-Vázquez, Elisa , Garza-Frias, Emiliano , Gentile, Angela , Gil-Fournier, Belén , de Araújo, Jéssica N G , Gómez-Duque, Mario , Gómez-Arrue, Javier , Gómez Carrera, Luis , Gómez García, María , Gómez Sacristán, Ángela , González-Neira, Anna , González Álvarez, Beatriz , González Bernaldo de Quirós, Fernán , González-Montelongo, Rafaela , González-Peñas, Javier , Gonzalez-Sagrado, Manuel , Gonzalo-Benito, Hugo , Gorgojo-Galindo, Oscar , Górgolas, Miguel , Guaragna, Florencia , Chaux, Jessica G , Guillén-Navarro, Encarna , Guillén-Guío, Beatriz , Guisado-Vasco, Pablo , Gutiérrez-Castañeda, Luz D , Gutiérrez-Bautista, Juan F , Heili-Frades, Sara , Jacomo, Rafael H , Hernández, Estefania , Hernández-Moro, Cristina , Hernández-Ortega, Luis D , Hernández-Pérez, Guillermo , Hernández-Vaquero, Rebeca , Herráez, Belén , Herranz, M Teresa , Herrera, María , Herrero, María José , Herrero-González, Antonio , Horcajada, Juan P , Imaz-Ayo, Natale , Intxausti-Urrutibeaskoa, Maider , Íñigo-Campos, Antonio , Íñiguez, María , Jara, Rubén , Jiménez, Ángel , Jiménez-Alfaro, Ignacio , Jiménez, Pilar , Jiménez-Sousa, María A , Jordan, Iolanda , Laguna-Goya, Rocío , Laorden, Daniel , Lasa-Lázaro, María , Lattig, María Claudia , Lauriente, Ailen , Liger Borja, Anabel , Llanos, Lucía , López-Bernús, Amparo , Lopez-Garcia, Esther , López-Granados, Eduardo , Lopez-Rodriguez, Rosario , López-Ruz, Miguel A , Lorente, Leonardo , Lorenzo-Salazar, José M , Lozano, José E , Lozano-Espinosa, María , Mahillo, Ignacio , Mancebo, Esther , Mar, Carmen , Marcelo Calvo, Cristina , Marcos-Delgado, Alba , Marcos, Miguel , Marín-Candón, Alicia , Mariscal-Aguilar, Pablo , Martin-Pedraza, Laura , Martin-Fernandez, Marta , Martín-López, Caridad , Martín-Oterino, José-Ángel , Martín, María Dolores , Martín, Vicente , Martín, María M , Martín-Vicente, María , Martinez, Amalia , Martínez-González, Óscar , Martínez, Ricardo , Martinez-Paz, Pedro , Díaz-Caneja, Covadonga M , Martínez-Nieto, Óscar , Martínez-López, Iciar , Martínez-Reséndez, Michel F , Martínez, Silvia , Martínez, Juan José , Martínez-Pérez, Ángel , Martínez-Ramas, Andrea , Martínez-Robles, Violeta , Marzal, Laura , Mazzeu, Juliana F , Medrano, Francisco J , Meijome, Xose M , Mejuto-Montero, Natalia , Mendes, Ingrid , Duarte, Alice L , Méndez-Echevarría, Ana , Mendoza Charris, Humberto , Merayo Macías, Eleuterio , Mercadillo, Fátima , Mercado-Sesma, Arieh R , Mínguez, Pablo , Molina-Roldán, Elena , Molina, Antonio J J , Montoya, Juan José , Pinho, Susana M T , Moreira-Escriche, Patricia , Morelos-Arnedo, Xenia , Moreno, Rocío , Moreno Cuerda, Víctor , Moreno-Docón, Antonio , Moreno-Escalante, Junior , Moreno Fernández, Alberto , Muñoz García, Patricia , Neira, Pablo , Nevado, Julián , Nieto-Gañán, Israel , Silbiger, Vivian N , Nuñez-Torres, Rocío , Obrador-Hevia, Antònia , Ocejo-Vinyals, J Gonzalo , Olivar, Virginia , Oliveira, Silviene F , Ondo, Lorena , Orfao, Alberto , Ortega-Paino, Eva , Ortega, Luis , Ortiz-López, Rocío , Ortiz-Flores, Fernando , Oteo, José A , Pacheco, Manuel , Pacheco-Miranda, Fredy Javier , Padilla-Conejo, Irene , Panadero-Fajardo, Sonia , Parellada, Mara , Pariente-Rodríguez, Roberto , Friaza, Vicente , Paz-Artal, Estela , Peces-Barba, Germán , Pedromingo Kus, Miguel S , Perales, Celia , Santos, Ney P C , Guegel, Genilson P , Pérez, María Jazmín , Pérez, Alexandra , Pérez-Matute, Patricia , Pérez, César , Pérez-de-Nanclares, Gustavo , Pérez-García, Felipe , Pérez, Patricia , Pérez-Tomás, M Elena , Perucho, Teresa , Pichardo, Lisbeth A , Ribeiro, Adriana P , Pinsach-Abuin, Mel Lina , Pinzón, Luz Adriana , Medeiros, Jeane F P , Pita, Guillermo , Pla-Juncà, Francesc , Planas-Serra, Laura , Pompa-Mera, Ericka N , Porras-Hurtado, Gloria L , Pujol, Aurora , Quevedo-Chávez, María Eugenia , Quijada, Maria Angeles , Ramiro-León, Soraya , Rascado Sedes, Pedro , Nunes, Joana F R , Recalde, Delia , Recio-Fernández, Emma , Resino, Salvador , Sousa, Renata R , Rivadeneira-Chamorro, Carlos S , Roa-Agudelo, Diana , Robelo Pardo, Montserrat , Fernandes, Marianne R , Rodríguez-Hernández, María A , Rodriguez-Palmero, Agustí , Rodríguez-Ruiz, Emilio , Rodriguez, Marilyn Johanna , Rodríguez-Artalejo, Fernando , Rodríguez-Ferrer, Marena , Rodríguez-Gallego, Carlos , Rodríguez-García, José A , Maya, Belén Rodríguez , Rodriguez-Nicolas, Antonio , Rodríguez-Novoa, German Ezequiel , Rodriguez-Urrego, Paula A , Rojo, Federico , Romero-Coronado, Andrea , Morilla, Rubén , Rondón-García, Filomeno , Rosales-Castillo, Antonio , Rubio, Cladelis , Olivera, María Rubio , Ruiz-Cabello, Francisco , Ruiz-Casares, Eva , Ruiz-Cubillan, Juan J , Ruiz-Hornillos, Javier , Ruiz, Montserrat , Ryan, Pablo , Salamanca, Hector D , Salazar-García, Lorena , Salgueiro-Origlia, Giorgina Gabriela , Sangil, Anna , Sánchez-Pernaute, Olga , Sánchez, Pedro-Luis , Sánchez López, Antonio J , Sánchez-Pablo, Clara , Sánchez-Prados, María Concepción , Sánchez-Real, Javier , Sánchez-Redondo, Jorge , Sancho-Sainz, Cristina , Sande, Esther , Santos, Arnoldo , Schlüter, Agatha , Segovia, Sonia , Serra-Llovich, Alex , Sevil-Puras, Fernando , Sevilla-Porras, Marta , Sicolo, Miguel A , Silván-Fuentes, Cristina , Moraes, Vitor M S , Souza, Vanessa S , Solé-Violán, Jordi , Soria, José Manuel , Sorlí, Jose V , Silva, Nayara S , Souto, Juan Carlos , Sprockel, John J , Suárez-Rama, José Javier , Suárez-Zamora, David A , Taboada-Fraga, Xiana , Tamayo, Eduardo , Tamayo-Velasco, Alvaro , Taracido-Fernández, Juan Carlos , Vasconcelos, Romero H T , Tellería, Carlos , Carratto, Thássia M T , Tenorio-Castaño, Jair Antonio , Teper, Alejandro , Araujo, Izabel M T , Torres-Macho, Juan , Torres-Tobar, Lilian , Torres-Gutiérrez, Ronald P , Troya, Jesús , Urioste, Miguel , Valencia-Ramos, Juan , Valido, Agustín , Vargas-Gallo, Juan Pablo , Varón, Belén , Vega, Tomas , Velasco-Quirce, Santiago , Vélez-Santamaría, Valentina , Víctor, Virginia , Vidán-Estévez, Julia , Silva, Gabriela V , Vieitez-Santiago, Miriam , Vilches, Carlos , Villalobos, Lavinia , Villar, Felipe , Villar-Garcia, Judit , Villaverde, Cristina , Villoslada-Blanco, Pablo , Virseda-Berdices, Ana , Costa, Tatiana X , Yáñez, Zuleima , Zapatero-Gaviria, Antonio , Zarate, Ruth , Zazo, Sandra , Flores, Carlos , Riancho, José A , Rojas-Martinez, Augusto
External publication Si
Means Communications Biology
Scope Article
Nature Científica
JCR Quartile 1
SJR Quartile 1
Publication date 19/02/2024
DOI 10.1038/s42003-024-05805-6
Abstract The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.
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